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Literature DB >> 8616818

Simultaneous expression of cadherin-11 in signet-ring cell carcinoma and stromal cells of diffuse-type gastric cancer.

T Shibata¹, A Ochiai, M Gotoh, R Machinami, S Hirohashi.

Abstract

We examined the expression of cadherin-11, a type II cadherin, in normal human tissues, cell lines and gastric cancer surgical specimens. Cadherin-11 was expressed widely in adult tissues, except the liver. It was expressed in fibroblast, mesothelial cell lines, and in only two signet ring cell carcinomas out of 16 various cancer cell lines. Cadherin-11 expression was detected in both signet ring cell carcinoma cells and surrounding fibroblasts of surgical specimens by in situ hybridization. These results suggest that cadherin-11 may play a role in the formation of diffuse-type gastric cancer through cancer-stromal interactions.

Entities: Disease Gene Species

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Year: 1996 PMID： 8616818 DOI： 10.1016/0304-3835(95)04047-1

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

18 in total

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Simultaneous expression of cadherin-11 in signet-ring cell carcinoma and stromal cells of diffuse-type gastric cancer.

1. Myofibroblast development is characterized by specific cell-cell adherens junctions.

2. Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo.

3. Cadherin-11 increases migration and invasion of prostate cancer cells and enhances their interaction with osteoblasts.

4. Identification of cadherin 11 as a mediator of dermal fibrosis and possible role in systemic sclerosis.

5. Dominant-negative E-cadherin inhibits the invasiveness of inflammatory breast cancer cells in vitro.

6. Cadherin-11 expression patterns in heart valves associate with key functions during embryonic cushion formation, valve maturation and calcification.

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