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Literature DB >> 8615840

Pentamidine uptake in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes.

Abstract

A transport system for pentamidine in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes has been identified and characterized. Pentamidine is not metabolized by these parasites. Its uptake process is saturable, carrier-mediated and energy-dependent. This drug does not inhibit purine or pyrimidine uptake, whereas it inhibits uptake of several amino acids non-competitively and that of putrescine and spermidine competitively. The results suggest that pentamidine shares polyamine-carrier systems in these parasites.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1996 PMID： 8615840 PMCID： PMC1217243 DOI： 10.1042/bj3150631

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

25 in total

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12 in total

1. Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.

Authors: Denise da Gama Jaén Batista; Marcos Meuser Batista; Gabriel Melo de Oliveira; Patrícia Borges do Amaral; Joseli Lannes-Vieira; Constança Carvalho Britto; Angela Junqueira; Marli Maria Lima; Alvaro José Romanha; Policarpo Ademar Sales Junior; Chad E Stephens; David W Boykin; Maria de Nazaré Correia Soeiro
Journal: Antimicrob Agents Chemother Date: 2010-05-10 Impact factor: 5.191

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Review 9. Comparative analysis of the omics technologies used to study antimonial, amphotericin B, and pentamidine resistance in leishmania.

Authors: Gagandeep Kaur; Bhawana Rajput
Journal: J Parasitol Res Date: 2014-05-12

10. Evaluation of the Leishmanicidal Activity of Rutaceae and Lauraceae Ethanol Extracts on Golden Syrian Hamster (Mesocricetus auratus) Peritoneal Macrophages.

Authors: N A Chávez Enciso; E D Coy-Barrera; O J Patiño; L E Cuca; Gabriela Delgado
Journal: Indian J Pharm Sci Date: 2014-05 Impact factor: 0.975