Literature DB >> 8615393

Protective Role of TNF-alpha in respiratory syncytial virus infection in vitro and in vivo.

K M Neuzil1, Y W Tang, B S Graham.   

Abstract

Respiratory syncytial virus (RSV) infection causes substantial morbidity in young children and immunocompromised adults, yet its pathogenesis is poorly understood. Because the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) may be important in host response to viral infection, HEp-2 cells were treated with TNF-alpha and mice were given TNF-alpha antibody before RSV infection. Pretreatment of HEp-2 cells with TNF-alpha inhibited RSV replication as determined by cytopathic effect. Respiratory syncytial virus-infected BALB/c mice treated with antibody to TNF-alpha had greater maximal weight loss and slower recovery time than control mice. These results suggest a protective role for TNF-alpha in RSV infection.

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Year:  1996        PMID： 8615393     DOI： 10.1097/00000441-199605000-00001

Source DB:  PubMed          Journal:  Am J Med Sci        ISSN： 0002-9629            Impact factor:   2.378


  24 in total

1.  The central conserved cystine noose of the attachment G protein of human respiratory syncytial virus is not required for efficient viral infection in vitro or in vivo.

Authors:  Michael N Teng; Peter L Collins
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

2.  Alternative mechanisms of respiratory syncytial virus clearance in perforin knockout mice lead to enhanced disease.

Authors:  S Aung; J A Rutigliano; B S Graham
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

3.  CD4(+) T-cell-mediated antiviral protection of the upper respiratory tract in BALB/c mice following parenteral immunization with a recombinant respiratory syncytial virus G protein fragment.

Authors:  H Plotnicky-Gilquin; A Robert; L Chevalet; J F Haeuw; A Beck; J Y Bonnefoy; C Brandt; C A Siegrist; T N Nguyen; U F Power
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

Review 4.  The immune response to respiratory syncytial virus infection: friend or foe?

Authors:  Robert C Welliver
Journal:  Clin Rev Allergy Immunol       Date:  2008-04       Impact factor: 8.667

5.  Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappaB-mediated innate antiviral response against human respiratory syncytial virus.

Authors:  Srikanth Kota; Ahmed Sabbah; Te Hung Chang; Rosalinda Harnack; Yan Xiang; Xiangzhi Meng; Santanu Bose
Journal:  J Biol Chem       Date:  2008-06-20       Impact factor: 5.157

6.  Anti-respiratory syncytial virus (RSV) neutralizing antibody decreases lung inflammation, airway obstruction, and airway hyperresponsiveness in a murine RSV model.

Authors:  Asunción Mejías; Susana Chávez-Bueno; Ana María Ríos; Jesús Saavedra-Lozano; Mónica Fonseca Aten; Jeanine Hatfield; Payal Kapur; Ana María Gómez; Hasan S Jafri; Octavio Ramilo
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

7.  Differential Responses by Human Respiratory Epithelial Cell Lines to Respiratory Syncytial Virus Reflect Distinct Patterns of Infection Control.

Authors:  Philippa Hillyer; Rachel Shepard; Megan Uehling; Mina Krenz; Faruk Sheikh; Kalyn R Thayer; Lei Huang; Lihan Yan; Debasis Panda; Cindy Luongo; Ursula J Buchholz; Peter L Collins; Raymond P Donnelly; Ronald L Rabin
Journal:  J Virol       Date:  2018-07-17       Impact factor: 5.103

8.  Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses.

Authors:  Santanu Bose; Niladri Kar; Ratan Maitra; Joseph A DiDonato; Amiya K Banerjee
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-05       Impact factor: 11.205

9.  Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis.

Authors:  Nahed Ismail; Emily C Crossley; Heather L Stevenson; David H Walker
Journal:  Infect Immun       Date:  2007-06-11       Impact factor: 3.441

Review 10.  Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology.

Authors:  John S Tregoning; Jürgen Schwarze
Journal:  Clin Microbiol Rev       Date:  2010-01       Impact factor: 26.132
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