BACKGROUND AND PURPOSE: Among patients with spontaneous cervical artery dissections, the risk of recurrent arterial dissection is relatively low at 1% per year, but this risk may be higher for patients with a family history of arterial dissections. We compared the risk of a recurrent arterial dissection in patients with familial versus non familial disease. METHODS: Long-term follow-up was established in 200 patients (104 women and 96 men with a mean age of 44.9 years) with spontaneous cervical artery dissections evaluated at a single institution between 1970 and 1990. RESULTS: Among the 200 patients, 10 (5%) were identified who had a family history of spontaneous arterial dissections. In a multivariate analysis, family history was the only significant variable associated with the risk of recurrent dissection (X2=15.51; P=.0001). A recurrent arterial dissection was identified in 5 (50%) of the 10 patients with familial disease compared with 11 (5.8%) of the 190 patients with nonfamilial disease, with an estimated relative risk of 6.3 (95% confidence interval, 2.2 to 18.3; P=.0007). CONCLUSIONS: Among patients with spontaneous cervical artery dissections, a family history of arterial dissection is an important risk factor for the development of a recurrent arterial dissection.
BACKGROUND AND PURPOSE: Among patients with spontaneous cervical artery dissections, the risk of recurrent arterial dissection is relatively low at 1% per year, but this risk may be higher for patients with a family history of arterial dissections. We compared the risk of a recurrent arterial dissection in patients with familial versus non familial disease. METHODS: Long-term follow-up was established in 200 patients (104 women and 96 men with a mean age of 44.9 years) with spontaneous cervical artery dissections evaluated at a single institution between 1970 and 1990. RESULTS: Among the 200 patients, 10 (5%) were identified who had a family history of spontaneous arterial dissections. In a multivariate analysis, family history was the only significant variable associated with the risk of recurrent dissection (X2=15.51; P=.0001). A recurrent arterial dissection was identified in 5 (50%) of the 10 patients with familial disease compared with 11 (5.8%) of the 190 patients with nonfamilial disease, with an estimated relative risk of 6.3 (95% confidence interval, 2.2 to 18.3; P=.0007). CONCLUSIONS: Among patients with spontaneous cervical artery dissections, a family history of arterial dissection is an important risk factor for the development of a recurrent arterial dissection.
Authors: Keng Yeow Tay; Jean Marie U-King-Im; Rikin A Trivedi; Nicholas J Higgins; Justin J Cross; John R Davies; Peter L Weissberg; Nagui M Antoun; Jonathan H Gillard Journal: Eur Radiol Date: 2005-01-27 Impact factor: 5.315
Authors: Stéphanie Debette; Barbara Goeggel Simonetti; Sabrina Schilling; Juan José Martin; Manja Kloss; Hakan Sarikaya; Ingrid Hausser; Stefan Engelter; Tiina M Metso; Alessandro Pezzini; Vincent Thijs; Emmanuel Touzé; Stefano Paolucci; Paolo Costa; Maria Sessa; Yves Samson; Yannick Béjot; Ayse Altintas; Antti J Metso; Dominique Hervé; Christoph Lichy; Simon Jung; Urs Fischer; Chantal Lamy; Armin Grau; Hugues Chabriat; Valeria Caso; Philippe A Lyrer; Christian Stapf; Turgut Tatlisumak; Tobias Brandt; Elisabeth Tournier-Lasserve; Dominique P Germain; Michael Frank; Ralf W Baumgartner; Caspar Grond-Ginsbach; Marie-Germaine Bousser; Didier Leys; Jean Dallongeville; Anna Bersano; Marcel Arnold Journal: Neurology Date: 2014-10-29 Impact factor: 9.910
Authors: Michał Polguj; Kazimierz Jędrzejewski; Mirosław Topol; Julia Wieczorek-Pastusiak; Agata Majos Journal: Anat Sci Int Date: 2012-09-07 Impact factor: 1.741