Chronic glomerulonephritis in childhood. Membranoproliferative glomerulonephritis, Henoch-Schönlein purpura nephritis, and IgA nephropathy.

The chronic glomerulonephritides that lead to permanent loss of renal function may present with an acute nephritic syndrome, nephrotic syndrome, or asymptomatic hematuria and proteinuria. Membranoproliferative glomerulonephritis, Henoch-Schönlein purpura nephritis, and IgA nephropathy are common childhood glomerulonephritides that may lead to chronic renal failure. Their clinical manifestations, natural history, and long-term prognosis are distinct. This article reviews various presentations of these common childhood glomerulonephritides and an approach to management and potential therapy.