Influence of leukotrienes B4 and C4, 12-hydroxyeicosatetraenoic acid, and erythro epimers of hepoxilin B3 on the plasticity of cholinoreceptors of neurons of the common snail.

The influences of a number of acyclic eicosanoids which are formed from arachidonic acid under the influence of 5- and 12-lipoxygenases on the plasticity of cholinoreceptors of neurons of the common snail, which was assessed on the basis of the degree of frequency depression of the amplitude of the inward current induced by local application of acetylcholine to the soma, were investigated in identified RPa3 and LPa3 neurons of the common snail using the method of bielectrode recording of the potential on the membrane. The plasticity of the cholinoreceptors was enhanced by leukotrienes B4 and C4, and was not altered by 12(S)-hydroxy-(5Z, 8Z, 10E, 14Z)-eicosatetraenoic acid, or by the threo and erythro epimers of hepoxilin B3. An inference is drawn regarding the regulation of the plasticity of cholinoreceptors by leukotrienes B4 and C4, which are formed under the influence of 5-lipoxygenase. One of these pathways includes inositol-1,4,5-triphosphate-dependent mobilization of deposited Ca2+.