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Literature DB >> 8612784

Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes.

B Robertson¹, D Owen, J Stow, C Butler, C Newland.

Abstract

We have examined the effects of two DTX homologues, toxin I and toxin K, on Kv1.1, Kv1.2 and Kv1.6 channels expressed in Xenopus oocytes. Toxin I blocked all three channels; in contrast, toxin K was selective for Kv1.1. Both toxins slowed channel activation and inactivation kinetics with 10 nM toxin I approximately doubling activation and inactivation time constants of Kv1.1. For the first time, we have demonstrated the selectivity of a DTX homologue for a single cloned Kv1 channel and suggest that these toxins may sterically hinder the conformational changes that occur during channel gating.

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Year: 1996 PMID： 8612784 DOI： 10.1016/0014-5793(96)00211-6

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

54 in total

1. Electrophysiological characterization of voltage-gated K(+) currents in cerebellar basket and purkinje cells: Kv1 and Kv3 channel subfamilies are present in basket cell nerve terminals.

Authors: A P Southan; B Robertson
Journal: J Neurosci Date: 2000-01-01 Impact factor: 6.167

2. Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons.

Authors: Patricia A Glazebrook; Angelina N Ramirez; John H Schild; Char-Chang Shieh; Thanh Doan; Barbara A Wible; Diana L Kunze
Journal: J Physiol Date: 2002-06-01 Impact factor: 5.182

3. Enhancement of signal-to-noise ratio and phase locking for small inputs by a low-threshold outward current in auditory neurons.

Authors: Gytis Svirskis; Vibhakar Kotak; Dan H Sanes; John Rinzel
Journal: J Neurosci Date: 2002-12-15 Impact factor: 6.167

4. Cav1.3 calcium channels are required for normal development of the auditory brainstem.

Authors: Jan J Hirtz; Michael Boesen; Nadine Braun; Joachim W Deitmer; Florian Kramer; Christian Lohr; Britta Müller; Hans Gerd Nothwang; Jörg Striessnig; Stefan Löhrke; Eckhard Friauf
Journal: J Neurosci Date: 2011-06-01 Impact factor: 6.167

5. 4-aminopyridine- and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus.

Authors: Vladimir P Zagorodnyuk; Bao Nan Chen; Marcello Costa; Simon J H Brookes
Journal: Br J Pharmacol Date: 2002-12 Impact factor: 8.739

Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes.

1. Electrophysiological characterization of voltage-gated K(+) currents in cerebellar basket and purkinje cells: Kv1 and Kv3 channel subfamilies are present in basket cell nerve terminals.

2. Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons.

3. Enhancement of signal-to-noise ratio and phase locking for small inputs by a low-threshold outward current in auditory neurons.

4. Cav1.3 calcium channels are required for normal development of the auditory brainstem.

5. 4-aminopyridine- and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus.

6. Subthreshold outward currents enhance temporal integration in auditory neurons.

7. Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion.

8. Two heteromeric Kv1 potassium channels differentially regulate action potential firing.

9. Functional profiling of neurons through cellular neuropharmacology.

10. Expression and biophysical properties of Kv1 channels in supragranular neocortical pyramidal neurones.