OBJECTIVE: To study the prevalence and determinants of glucose intolerance in a general Caucasian population. RESEARCH DESIGN AND METHODS: A random sample of 50- to 74-year old Caucasians (n = 2,484) underwent oral glucose tolerance tests. Multiple regression analyses were performed to study the association of 2-h postload plasma glucose values with potential determinants. RESULTS: Prevalence of known and newly detected diabetes and impaired glucose tolerance was 3.6, 4.8, and 10.3%, respectively. In women, but not in men, the association of body mass index with 2-h glucose was fully accounted for by the waist-to-hip ratio. Maternal history of diabetes was twice as prevalent as paternal history, but paternal history only was associated with 2-h glucose. In addition, paternal history was a stronger determinant in men than in women. An independent positive association with 2-h plasma glucose was found for alcohol use of > 30 g/day in women and for intake of total protein, animal protein, and polyunsaturated fatty acids in men. An independent inverse association with 2-h plasma glucose was demonstrated for height (both sexes), alcohol use of < or = 30 g/day (both sexes), energy intake (in men), and, unexpectedly, current smoking (in men). CONCLUSIONS: The prevalence of diabetes in elderly Caucasians was 8.3%. In men, dietary habits may unfavorably influence glucose tolerance independent of obesity.
OBJECTIVE: To study the prevalence and determinants of glucose intolerance in a general Caucasian population. RESEARCH DESIGN AND METHODS: A random sample of 50- to 74-year old Caucasians (n = 2,484) underwent oral glucose tolerance tests. Multiple regression analyses were performed to study the association of 2-h postload plasma glucose values with potential determinants. RESULTS: Prevalence of known and newly detected diabetes and impaired glucose tolerance was 3.6, 4.8, and 10.3%, respectively. In women, but not in men, the association of body mass index with 2-h glucose was fully accounted for by the waist-to-hip ratio. Maternal history of diabetes was twice as prevalent as paternal history, but paternal history only was associated with 2-h glucose. In addition, paternal history was a stronger determinant in men than in women. An independent positive association with 2-h plasma glucose was found for alcohol use of > 30 g/day in women and for intake of total protein, animal protein, and polyunsaturated fatty acids in men. An independent inverse association with 2-h plasma glucose was demonstrated for height (both sexes), alcohol use of < or = 30 g/day (both sexes), energy intake (in men), and, unexpectedly, current smoking (in men). CONCLUSIONS: The prevalence of diabetes in elderly Caucasians was 8.3%. In men, dietary habits may unfavorably influence glucose tolerance independent of obesity.
Authors: Erwin Reiling; Jana V van Vliet-Ostaptchouk; Esther van 't Riet; Timon W van Haeften; Pascal A Arp; Torben Hansen; Dennis Kremer; Marlous J Groenewoud; Els C van Hove; Johannes A Romijn; Jan W A Smit; Giel Nijpels; Robert J Heine; André G Uitterlinden; Oluf Pedersen; P Eline Slagboom; Johannes A Maassen; Marten H Hofker; Leen M 't Hart; Jacqueline M Dekker Journal: Eur J Hum Genet Date: 2009-02-11 Impact factor: 4.246
Authors: T den Heijer; S E Vermeer; E J van Dijk; N D Prins; P J Koudstaal; A Hofman; M M B Breteler Journal: Diabetologia Date: 2003-11-01 Impact factor: 10.122
Authors: Amber A W A van der Heijden; Monica M Ortegon; Louis W Niessen; Giel Nijpels; Jacqueline M Dekker Journal: Diabetes Care Date: 2009-11 Impact factor: 19.112
Authors: E Reiling; B Jafar-Mohammadi; E van 't Riet; M N Weedon; J V van Vliet-Ostaptchouk; T Hansen; R Saxena; T W van Haeften; P A Arp; S Das; G Nijpels; M J Groenewoud; E C van Hove; A G Uitterlinden; J W A Smit; A D Morris; A S F Doney; C N A Palmer; C Guiducci; A T Hattersley; T M Frayling; O Pedersen; P E Slagboom; D M Altshuler; L Groop; J A Romijn; J A Maassen; M H Hofker; J M Dekker; M I McCarthy; L M 't Hart Journal: Diabetologia Date: 2009-10-22 Impact factor: 10.122