Literature DB >> 8611968

Determination of ofloxacin in human plasma using high-performance liquid chromatography and fluorescence detection.

J Macek1, P Ptácek.   

Abstract

A new method for the determination of ofloxacin in human plasma was developed. Plasma proteins were precipitated with acetonitrile, the supernatant concentrated and injected into a reversed-phase C18 column. Enoxacin was used as an internal standard. The fluorimetric detection was performed at 282 nm for excitation and 450 nm for emission. Limit of quantitation was 20 ng/ml and the calibration curve was linear up to 6900 ng/ml.

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Year:  1995        PMID: 8611968     DOI: 10.1016/0378-4347(95)00263-5

Source DB:  PubMed          Journal:  J Chromatogr B Biomed Appl        ISSN: 1572-6495


  3 in total

1.  Supramolecular Study on the Interaction Between Ofloxacin and Methyl β-Cyclodextrin by Fluorescence Spectroscopy and its Analytical Application.

Authors:  Abdalla A Elbashir; Nuha Fathi Ali Dsugi; Hassan Y Aboul-Enein
Journal:  J Fluoresc       Date:  2013-09-21       Impact factor: 2.217

2.  Ofloxacin-loaded liposomes: in vitro activity and drug accumulation in bacteria.

Authors:  P M Furneri; M Fresta; G Puglisi; G Tempera
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

3.  A UPLC-MS Method for the Determination of Ofloxacin Concentrations in Aqueous Humor.

Authors:  Panagiotis Plotas; Charalampos Anastasopoulos; Olga E Makri; Michalis Leotsinidis; Constantine D Georgakopoulos
Journal:  Anal Chem Insights       Date:  2014-05-05
  3 in total

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