| Literature DB >> 8611693 |
S R Weiler1, S Mou, C S DeBerry, J R Keller, F W Ruscetti, D K Ferris, D L Longo, D Linnekin.
Abstract
Stem cell factor (SCF) is a hematopoietic growth factor that interacts with the receptor tyrosine kinase, c-kit. We have found that SCF-stimulates rapid and transient tyrosine phosphorylation of JAK2 in human and murine cell lines, as well as in normal human progenitor cells. JAK2 and c-kit were associated in unstimulated cells with further recruitment of JAK2 to the c-kit receptor complex after SCF stimulation. Treatment of cells with JAK2 antisense oligonucleotides resulted in a 46% decrease in SCF-induced proliferation. These data demonstrate that SCF induces tyrosine phosphorylation of JAK2 and suggest that JAK2 is a component of the SCF signal transduction pathway.Entities:
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Year: 1996 PMID： 8611693
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113