Literature DB >> 8611650

Ageing is associated in females with a decline in the content and activity on the b-c1 complex in skeletal muscle mitochondria.

D Boffoli1, S C Scacco, R Vergari, M T Persio, G Solarino, R Laforgia, S Papa.   

Abstract

The activity of cytochrome-c oxidase [E.C. 1.9.3.1] and b-c1 complex [E.C. 1.10.2.2] and the content of cytochromes b, c + c1 and a + a3 in human skeletal muscle mitochondria from orthopaedic patients (108 women and 68 males), of age ranging between 10 and 50 years, have been analyzed. The activity of cytochrome c-oxidase declines with age both in females and males. The activity of b-c1 complex, which in young females is significantly higher than in young males, declines sharply in females, but not in males, with ageing. These results reveal that the content of active b-c1 complex in muscle mitochondria is specifically controlled by female sex hormones.

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Year:  1996        PMID： 8611650     DOI： 10.1016/0925-4439(95)00107-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  15 in total

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