Literature DB >> 8611366

Cyclosporine-induced transient renal hypoperfusion in adolescent transplant recipients.

L Dello Strologo1, L Massella, G Rizzoni.   

Abstract

We investigated the acute hemodynamic effect of a single oral dose of cyclosporine A (CsA) given as part of the immunosuppressive schedule in six adolescents with renal transplants. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amino-hippuric acid for 12 h. A fall in both GFR and RPF was observed 4-6 h after peak plasma CsA levels. No significant correlation was found with CsA dosage or any pharmacokinetic parameters. This study demonstrates that CsA also has a vasoconstrictory effect in adolescent recipients; this could be one of the causes of its nephrotoxicity.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8611366     DOI： 10.1007/bf00863455

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  8 in total

Review 1.  Cyclosporine pharmacokinetics in pediatric transplant recipients.

Authors:  T L Wandstrat; T J Schroeder; S A Myre
Journal:  Ther Drug Monit       Date:  1989-09       Impact factor: 3.681

2.  THE RENAL CLEARANCES OF SUBSTITUTED HIPPURIC ACID DERIVATIVES AND OTHER AROMATIC ACIDS IN DOG AND MAN.

Authors:  H W Smith; N Finkelstein; L Aliminosa; B Crawford; M Graber
Journal:  J Clin Invest       Date:  1945-05       Impact factor: 14.808

3.  Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity.

Authors:  S R Smith; E A Creech; A V Schaffer; L L Martin; A Rakhit; F L Douglas; P E Klotman; T M Coffman
Journal:  Kidney Int       Date:  1992-01       Impact factor: 10.612

4.  Role of endothelin in cyclosporine-induced glomerular dysfunction.

Authors:  V Kon; M Sugiura; T Inagami; B R Harvie; I Ichikawa; R L Hoover
Journal:  Kidney Int       Date:  1990-06       Impact factor: 10.612

5.  The impact of cyclosporine therapy on the occurrence of infection in the renal transplant recipient.

Authors:  N E Tolkoff-Rubin; R H Rubin
Journal:  Transplant Proc       Date:  1986-04       Impact factor: 1.066

6.  Daily renal hypoperfusion induced by cyclosporine in patients with renal transplantation.

Authors:  N Perico; P Ruggenenti; F Gaspari; L Mosconi; A Benigni; C S Amuchastegui; F Gasparini; G Remuzzi
Journal:  Transplantation       Date:  1992-07       Impact factor: 4.939

7.  Chronic injury of human renal microvessels with low-dose cyclosporine therapy.

Authors:  B D Myers; L Newton; C Boshkos; J A Macoviak; W H Frist; G C Derby; M G Perlroth; R K Sibley
Journal:  Transplantation       Date:  1988-11       Impact factor: 4.939

8.  Cyclosporine-associated chronic nephropathy.

Authors:  B D Myers; J Ross; L Newton; J Luetscher; M Perlroth
Journal:  N Engl J Med       Date:  1984-09-13       Impact factor: 91.245
  8 in total
  2 in total

1.  Long-term renal function in heart transplant children on cyclosporine treatment.

Authors:  Luca Dello Strologo; Francesco Parisi; Antonia Legato; Claudia Pontesilli; Anna Pastore; Lucilla Ravà; Alberto E Tozzi; Gianfranco Rizzoni
Journal:  Pediatr Nephrol       Date:  2006-02-21       Impact factor: 3.714

Review 2.  Role of hypertension in kidney transplant recipients.

Authors:  Charalampos Loutradis; Pantelis Sarafidis; Smaragdi Marinaki; Miriam Berry; Richard Borrows; Adnan Sharif; Charles J Ferro
Journal:  J Hum Hypertens       Date:  2021-05-04       Impact factor: 3.012
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.