Literature DB >> 861136

Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response.

J K Aronson, D G Grahame-Smith, K F Hallis, A Hibble, F Wigley.   

Abstract

1 An in vitro technique is described for measuring the uptake of 86Rb by human erythrocytes. 2 Fifteen patients were treated with digoxin for atrial fibrillation and other fast arrhythmias. 3 86Rb uptake by the patients' own red cells fell from pre-treatment values during digitalization. 4 The therapeutic response of patients with atrial fibrillation correlated better with the changes in 86Rb uptake than with plasma digoxin concentrations.

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Year:  1977        PMID： 861136      PMCID： PMC1429008          DOI： 10.1111/j.1365-2125.1977.tb00697.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  23 in total

1.  Proceedings: The influence of extracellular potassium ions on the action of ouabain on membrane currents in sheep Purkinje fibres.

Authors:  I Cohen; J Daut; D Noble
Journal:  J Physiol       Date:  1975-07       Impact factor: 5.182

2.  Proceedings: The influence of low doses of ouabain and potassium ions on sheep Purkinje fibre contractility.

Authors:  B E Blood
Journal:  J Physiol       Date:  1975-09       Impact factor: 5.182

3.  AN ION TRANSPORT DEFECT IN ERYTHROCYTES FROM UREMIC PATIENTS.

Authors:  L G WELT; J R SACHS; T J MCMANUS
Journal:  Trans Assoc Am Physicians       Date:  1964

4.  Changes in the erythrocyte potassium in patients with cardiac failure treated with digitalis.

Authors:  T C CLIFFORD; W BEAUTYMAN
Journal:  Clin Chem       Date:  1958-08       Impact factor: 8.327

5.  [Cardiac glycosides as inhibitors of active potassium and sodium transport by erythrocyte membrane].

Authors:  H J SCHATZMANN
Journal:  Helv Physiol Pharmacol Acta       Date:  1953

6.  A comparison of potassium 42, rubidium 86, and cesium 134 as tracers of potassium in the study of cation metabolism of human erythrocytes in vitro.

Authors:  W D LOVE; G E BURCH
Journal:  J Lab Clin Med       Date:  1953-03

7.  Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.

Authors:  D J Boullin; H F Woods; R P Grimes; D G Grahame-Smith
Journal:  Br J Clin Pharmacol       Date:  1975-02       Impact factor: 4.335

8.  The plasma digoxin concentration, red cell rubidium 86 uptake and control of ventricular rate in patients being digitalized for artrial fibrilation.

Authors:  A G Hibble; D G Grahame-Smith
Journal:  Clin Sci       Date:  1972-01       Impact factor: 6.124

9.  Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution.

Authors:  J K Aronson; D G Grahame-Smith
Journal:  Br J Clin Pharmacol       Date:  1977-04       Impact factor: 4.335

10.  Effect of digoxin on human red blood cell electrolytes.

Authors:  M Kettlewell; A Nowers; R White
Journal:  Br J Pharmacol       Date:  1972-01       Impact factor: 8.739
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  16 in total

1.  Increase in Na+/K+ pump numbers in vivo in healthy volunteers taking oral lithium carbonate and further upregulation in response to lithium in vitro.

Authors:  I J Antia; C E Dorkins; A J Wood; J K Aronson
Journal:  Br J Clin Pharmacol       Date:  1992-12       Impact factor: 4.335

2.  David Grahame Grahame-Smith: clinical pharmacologist. 1933-2011.

Authors:  Jeffrey K Aronson
Journal:  Br J Clin Pharmacol       Date:  2012-05       Impact factor: 4.335

3.  Clinical, haemodynamic, and pharmacological effects of withdrawal and reintroduction of digoxin in patients with heart failure in sinus rhythm after long term treatment.

Authors:  S E Pugh; N J White; J K Aronson; D G Grahame-Smith; J G Bloomfield
Journal:  Br Heart J       Date:  1989-06

Review 4.  Clinical relevance of pharmacokinetics.

Authors:  G Tognoni; C Bellantuono; M Bonati; M D'Incalci; M Gerna; R Latini; M Mandelli; M G Porro; E Riva
Journal:  Clin Pharmacokinet       Date:  1980 Mar-Apr       Impact factor: 6.447

5.  Lack of effect of phenytoin on functions related to Na+,K+-ATPase activity of the intact erythrocytes of epileptic patients.

Authors:  J K Aronson; D P Geaney; D G Grahame-Smith; J C Carver; K F Hallis
Journal:  Br J Clin Pharmacol       Date:  1981-07       Impact factor: 4.335

Review 6.  Indications for the measurement of plasma digoxin concentrations.

Authors:  J K Aronson
Journal:  Drugs       Date:  1983-09       Impact factor: 9.546

7.  The effect of digoxin on 86rubidium uptake by erythrocytes from mothers and babies.

Authors:  J G Kelly; R M McMillen; D G McDevitt
Journal:  Br J Clin Pharmacol       Date:  1983-01       Impact factor: 4.335

8.  Measurement of specific [3H]-ouabain binding to different types of human leucocytes.

Authors:  N A Boon; V M Oh; E A Taylor; T Johansen; J K Aronson; D G Grahame-Smith
Journal:  Br J Clin Pharmacol       Date:  1984-08       Impact factor: 4.335

Review 9.  Clinical pharmacokinetics of digoxin 1980.

Authors:  J K Aronson
Journal:  Clin Pharmacokinet       Date:  1980 Mar-Apr       Impact factor: 6.447

10.  Erythrocytic cation transport receptor numbers and activity in pregnancies complicated by essential hypertension and pre-eclampsia.

Authors:  J K Aronson; M P Moore; C W Redman; C Harper
Journal:  Br Med J (Clin Res Ed)       Date:  1984-05-05
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