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Literature DB >> 8609149

Structural alterations in the transcription factor PEBP2/CBF linked to four different types of leukemia.

Abstract

Polyomavirus enhancer binding protein 2 (PEBP2), also called core binding factor (CBF), is a heterodimer composed of the alpha and the beta subunits. Structural alterations of each of the two subunits generated by recurrent chromosome translocations/inversion are associated with acute myeloid leukemia or acute lymphoblastic leukemia. Chimeric proteins containing a part of either the alpha or beta subunits have a potential to affect the transcriptional regulation through the PEBP2/CBF site. Structure and function of PEBP2/CBF and possible mechanisms of leukemogenesis caused by the chimeric proteins are summarized.

Entities: Disease Species

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Year: 1996 PMID： 8609149 DOI： 10.1007/bf01261402

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

45 in total

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Journal: Genomics Date: 1995-04-10 Impact factor: 5.736

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Authors: S C Bae; E Takahashi; Y W Zhang; E Ogawa; K Shigesada; Y Namba; M Satake; Y Ito
Journal: Gene Date: 1995-07-04 Impact factor: 3.688

7 in total

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Authors: Y W Zhang; S C Bae; G Huang; Y X Fu; J Lu; M Y Ahn; Y Kanno; T Kanno; Y Ito
Journal: Mol Cell Biol Date: 1997-07 Impact factor: 4.272

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Journal: Proc Natl Acad Sci U S A Date: 1998-02-17 Impact factor: 11.205

4. Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms.

Authors: A Pozner; D Goldenberg; V Negreanu; S Y Le; O Elroy-Stein; D Levanon; Y Groner
Journal: Mol Cell Biol Date: 2000-04 Impact factor: 4.272