Literature DB >> 8608270

The biosynthesis of Lewis X in Helicobacter pylori.

N W Chan1, K Stangier, R Sherburne, D E Taylor, Y Zhang, N J Dovichi, M M Palcic.   

Abstract

The biosynthesis of the Lewis X determinant (Gal beta 1-4 [Fuc alpha 1-3]GlcNAc beta-) in three strains of Helicobacter pylori has been investigated. Strains UA 861, UA 802 and UA 1182 contain alpha 1,3 fucosyltransferase and beta 1,4 galactosyltransferase activities that synthesize the Lewis X structure by the transfer of monosaccharides from GDP-fucose and UDP-galactose donors, respectively. The enzyme reaction products that formed were characterized by capillary zone electrophoresis and by 1H-NMR spectroscopy. The biosynthetic pathway is therefore identical to that found in humans. In the three strains, the fucosyltransferase and galactosyltransferase activities differed in various cellular fractions. Km values for their donor and acceptor substrates also differed.

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Year:  1995        PMID： 8608270     DOI： 10.1093/glycob/5.7.683

Source DB:  PubMed          Journal:  Glycobiology        ISSN： 0959-6658            Impact factor:   4.313


  14 in total

1.  Helicobacter hepaticus Hh0072 gene encodes a novel alpha1-3-fucosyltransferase belonging to CAZy GT11 family.

Authors:  Lei Zhang; Kam Lau; Jiansong Cheng; Hai Yu; Yanhong Li; Go Sugiarto; Shengshu Huang; Li Ding; Vireak Thon; Peng G Wang; Xi Chen
Journal:  Glycobiology       Date:  2010-05-06       Impact factor: 4.313

2.  Host Lewis phenotype-dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys.

Authors:  Hans-Peter Wirth; Manqiao Yang; Edgardo Sanabria-Valentín; Douglas E Berg; André Dubois; Martin J Blaser
Journal:  FASEB J       Date:  2006-05-23       Impact factor: 5.191

3.  Fosfomycin reduces CD15s-related antigen expression of Streptococcus pyogenes.

Authors:  K Hirota; K Murakami; K Nemoto; T Ono; T Matsuo; H Kumon; Y Miyake
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

4.  Genotypic and phenotypic variation of Lewis antigen expression in geographically diverse Helicobacter pylori isolates.

Authors:  Mary Ann Pohl; William Zhang; Sunny N Shah; Edgardo L Sanabria-Valentín; Guillermo I Perez-Perez; Martin J Blaser
Journal:  Helicobacter       Date:  2011-12       Impact factor: 5.753

5.  Expression of the human cell surface glycoconjugates Lewis x and Lewis y by Helicobacter pylori isolates is related to cagA status.

Authors:  H P Wirth; M Yang; M Karita; M J Blaser
Journal:  Infect Immun       Date:  1996-11       Impact factor: 3.441

6.  Lipooligosaccharide of Campylobacter jejuni: similarity with multiple types of mammalian glycans beyond gangliosides.

Authors:  R Scott Houliston; Evgeny Vinogradov; Monika Dzieciatkowska; Jianjun Li; Frank St Michael; Marie-France Karwaski; Denis Brochu; Harold C Jarrell; Craig T Parker; Nobuhiro Yuki; Robert E Mandrell; Michel Gilbert
Journal:  J Biol Chem       Date:  2011-01-21       Impact factor: 5.157

7.  Exploiting bacterial glycosylation machineries for the synthesis of a Lewis antigen-containing glycoprotein.

Authors:  Isabelle Hug; Blake Zheng; Bela Reiz; Randy M Whittal; Messele A Fentabil; John S Klassen; Mario F Feldman
Journal:  J Biol Chem       Date:  2011-08-30       Impact factor: 5.157

8.  CE-MALDI interface based on inkjet technology.

Authors:  Michael W Vannatta; Colin D Whitmore; Norman J Dovichi
Journal:  Electrophoresis       Date:  2009-12       Impact factor: 3.535

9.  The ruminant parasite Haemonchus contortus expresses an alpha1,3-fucosyltransferase capable of synthesizing the Lewis x and sialyl Lewis x antigens.

Authors:  R A DeBose-Boyd; A K Nyame; D P Jasmer; R D Cummings
Journal:  Glycoconj J       Date:  1998-08       Impact factor: 2.916

10.  One-pot multienzyme synthesis of Lewis x and sialyl Lewis x antigens.

Authors:  Hai Yu; Kam Lau; Yanhong Li; Go Sugiarto; Xi Chen
Journal:  Curr Protoc Chem Biol       Date:  2012-09-01
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