Literature DB >> 8608011

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling.

M M Chou1, J Blenis.   

Abstract

The activation of the 70kDa S6 kinase, pp70S6k, is a well documented mitogenic response, yet until recently little was known of how pp70S6k is activated, or of the identities of its crucial targets. The past year has revealed the complexity of pp70S6k regulation, with the overriding theme being that enzymes which have proven or putative roles in phospholipid metabolism mediate its activation. Studies also indicate that pp70S6k may regulate many more pathways than previously recognized.

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Year:  1995        PMID： 8608011     DOI： 10.1016/0955-0674(95)80064-6

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  62 in total

1.  S6 phosphorylation-independent pathways regulate translation of 5'-terminal oligopyrimidine tract-containing mRNAs in differentiating hematopoietic cells.

Authors:  Diane Barth-Baus; Carl A Stratton; Lou Parrott; Howard Myerson; Oded Meyuhas; Dennis J Templeton; Gary E Landreth; Jack O Hensold
Journal:  Nucleic Acids Res       Date:  2002-05-01       Impact factor: 16.971

2.  Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase.

Authors:  M A Wilson; A R Burt; G Milligan; N G Anderson
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

3.  The conserved phosphoinositide 3-kinase pathway determines heart size in mice.

Authors:  T Shioi; P M Kang; P S Douglas; J Hampe; C M Yballe; J Lawitts; L C Cantley; S Izumo
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

Review 4.  Staying alive: metabolic adaptations to quiescence.

Authors:  James R Valcourt; Johanna M S Lemons; Erin M Haley; Mina Kojima; Olukunle O Demuren; Hilary A Coller
Journal:  Cell Cycle       Date:  2012-05-01       Impact factor: 4.534

5.  PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation.

Authors:  Jun Sun; Crystal S Conn; Yan Han; Vincent Yeung; Shu-Bing Qian
Journal:  J Biol Chem       Date:  2010-12-22       Impact factor: 5.157

6.  Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway.

Authors:  J S Koh; W Lieberthal; S Heydrick; J S Levine
Journal:  J Clin Invest       Date:  1998-08-15       Impact factor: 14.808

7.  A phosphatidylinositol 3-kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope-induced transformation of NIH 3T3 cells.

Authors:  M Palmarini; N Maeda; C Murgia; C De-Fraja; A Hofacre; H Fan
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

8.  Inhibition of NF-kappaB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes.

Authors:  P Papeleu; A Wullaert; G Elaut; T Henkens; M Vinken; G Laus; D Tourwé; R Beyaert; V Rogiers; T Vanhaecke
Journal:  Cell Prolif       Date:  2007-10       Impact factor: 6.831

9.  Divergence in signaling pathways involved in promotion of cell viability mediated by bFGF, NGF, and EGF in PC12 cells.

Authors:  Takakazu Kawamata; Tomoko Yamaguchi; Kazuo Shin-ya; Tomokatsu Hori
Journal:  Neurochem Res       Date:  2003-08       Impact factor: 3.996

10.  Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.

Authors:  H Shima; M Pende; Y Chen; S Fumagalli; G Thomas; S C Kozma
Journal:  EMBO J       Date:  1998-11-16       Impact factor: 11.598
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