Literature DB >> 8607837

Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1.

M Yasunami1, K Suzuki, H Maruyama, H Kawakami, Y Nagai, M Hagiwara, H Ohkubo.   

Abstract

We cloned a novel basic helix-loop-helix protein, NDRF (NeuroD-related factor), cDNA. NDRF contains 383 amino acids and exhibits 53.4% and 52.2% sequence identity to NeuroD and MATH-2/NEX-1, respectively. NDRF mRNA appears in the brain of 12-day-old mouse embryos and is localized in certain regions of the adult brain, such as the hippocampus, dentate gyrus and cerebellum, Thus, the structure and expression patterns of NDRF are similar to but distinct from those of NeuroD and MATH-2/NEX-1, suggesting that NDRF may play distinct roles in neural development and plasticity as a novel member of the NeuroD family.

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Year:  1996        PMID： 8607837     DOI： 10.1006/bbrc.1996.0476

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Conversion of ectoderm into a neural fate by ATH-3, a vertebrate basic helix-loop-helix gene homologous to Drosophila proneural gene atonal.

Authors:  K Takebayashi; S Takahashi; C Yokota; H Tsuda; S Nakanishi; M Asashima; R Kageyama
Journal:  EMBO J       Date:  1997-01-15       Impact factor: 11.598

2.  Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice.

Authors:  F J Naya; H P Huang; Y Qiu; H Mutoh; F J DeMayo; A B Leiter; M J Tsai
Journal:  Genes Dev       Date:  1997-09-15       Impact factor: 11.361

3.  Identification of the C-terminal activation domain of the NeuroD-related factor (NDRF).

Authors:  Y Konishi; T Aoki; N Ohkawa; T Matsu-Ura; K Mikoshiba; T Tamura
Journal:  Nucleic Acids Res       Date:  2000-06-15       Impact factor: 16.971

4.  Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus.

Authors:  M H Schwab; A Bartholomae; B Heimrich; D Feldmeyer; S Druffel-Augustin; S Goebbels; F J Naya; S Zhao; M Frotscher; M J Tsai; K A Nave
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

5.  Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice.

Authors:  M H Schwab; S Druffel-Augustin; P Gass; M Jung; M Klugmann; A Bartholomae; M J Rossner; K A Nave
Journal:  J Neurosci       Date:  1998-02-15       Impact factor: 6.167

6.  NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.

Authors:  M B McCormick; R M Tamimi; L Snider; A Asakura; D Bergstrom; S J Tapscott
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272
  6 in total

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