Literature DB >> 8606806

Hippocampal long-term depression: arachidonic acid as a potential retrograde messenger.

V Y Bolshakov1, S A Siegelbaum.   

Abstract

Long-term depression (LTD) was studied in hippocampal slices from neonatal rats at the synapse between CA3 and CA1 pyramidal neurons. The induction of LTD requires the pairing of Ca2+ influx into the postsynaptic CA1 neuron through voltage-gated calcium channels with activation of metabotropic glutamate receptors. The expression of this LTD is at least partly presynaptic, implying the need for a retrograde messenger. We present evidence that arachidonic acid might serve such a function. Thus, arachidonic acid applications simulate LTD whereas blockade of arachidonic acid release inhibits LTD.

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Year:  1995        PMID： 8606806     DOI： 10.1016/0028-3908(95)00127-r

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  12 in total

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