Literature DB >> 8606766

Essential flexibility in the T-cell recognition of antigen.

G J Kersh1, P M Allen.   

Abstract

alpha beta T cells specifically recognize a ligand composed of a peptide bound to a self-major-histocompatibility-complex molecule, but the recognition of slightly altered ligands by T cells can lead to a partial activation. This flexibility is crucial for T-cell development and can have both beneficial and harmful effects on peripheral T cells.

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Year:  1996        PMID： 8606766     DOI： 10.1038/380495a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  67 in total

1.  Sequential requirements of the N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of FcepsilonRI signaling.

Authors:  Z i Honda; T Suzuki; H Kono; M Okada; T Yamamoto; C Ra; Y Morita; K Yamamoto
Journal:  Mol Cell Biol       Date:  2000-03       Impact factor: 4.272

2.  Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact.

Authors:  Y Fukui; T Oono; J P Cabaniols; K Nakao; K Hirokawa; A Inayoshi; T Sanui; J Kanellopoulos; E Iwata; M Noda; M Katsuki; P Kourilsky; T Sasazuki
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

3.  Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands.

Authors:  W C Kieper; S C Jameson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

Review 4.  Heterologous immunity between viruses.

Authors:  Raymond M Welsh; Jenny W Che; Michael A Brehm; Liisa K Selin
Journal:  Immunol Rev       Date:  2010-05       Impact factor: 12.988

Review 5.  Defining the parameters necessary for T-cell recognition of ligands that vary in potency.

Authors:  Neely E Kilgore; Mandy L Ford; Carrie D Margot; Daniel S Jones; Peter Reichardt; Brian D Evavold
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

6.  The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming.

Authors:  Jacques Banchereau; LuAnn Thompson-Snipes; Sandra Zurawski; Jean-Philippe Blanck; Yanying Cao; Sandra Clayton; Jean-Pierre Gorvel; Gerard Zurawski; Eynav Klechevsky
Journal:  Blood       Date:  2012-04-25       Impact factor: 22.113

Review 7.  How specificity for self-peptides shapes the development and function of regulatory T cells.

Authors:  Donald M Simons; Cristina Cozzo Picca; Soyoung Oh; Olivia A Perng; Malinda Aitken; Jan Erikson; Andrew J Caton
Journal:  J Leukoc Biol       Date:  2010-05-21       Impact factor: 4.962

8.  High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics.

Authors:  Stephen P Persaud; David L Donermeyer; K Scott Weber; David M Kranz; Paul M Allen
Journal:  Mol Immunol       Date:  2010-03-23       Impact factor: 4.407

9.  Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37.

Authors:  Y Elaine Lau; Dawn M E Bowdish; Celine Cosseau; Robert E W Hancock; Donald J Davidson
Journal:  Am J Respir Cell Mol Biol       Date:  2005-12-09       Impact factor: 6.914

10.  Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.

Authors:  Yili Li; Yuping Huang; Jessica Lue; Jacqueline A Quandt; Roland Martin; Roy A Mariuzza
Journal:  EMBO J       Date:  2005-08-04       Impact factor: 11.598
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