Literature DB >> 8605628

Crystal structure of the macrophage migration inhibitory factor from rat liver.

M Suzuki1, H Sugimoto, A Nakagawa, I Tanaka, J Nishihira, M Sakai.   

Abstract

The tertiary structure of the macrophage migration inhibitory factor (MIF) from rat liver (12,300 Mr) is presented at 2.2 A resolution. Each monomer consists of two beta/alpha/beta motifs aligned in quasi two-fold symmetry, comprising a domain consisting of a four-stranded mixed beta-sheet and two antiparallel alpha-helices. The protein exists as a trimer in the crystal. An extra beta-strand that is almost perpendicular to the other beta-strands joins to the beta-sheet of the neighbouring monomer in the trimer. Unexpected similarities were detected between MIF and two kinds of isomerase.

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Year:  1996        PMID： 8605628     DOI： 10.1038/nsb0396-259

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  53 in total

Review 1.  D-dopachrome tautomerase (D-DT or MIF-2): doubling the MIF cytokine family.

Authors:  Melanie Merk; Robert A Mitchell; Stefan Endres; Richard Bucala
Journal:  Cytokine       Date:  2012-04-14       Impact factor: 3.861

2.  Dali/FSSP classification of three-dimensional protein folds.

Authors:  L Holm; C Sander
Journal:  Nucleic Acids Res       Date:  1997-01-01       Impact factor: 16.971

3.  Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate.

Authors:  Joel D A Tyndall; Hongqi Lue; Malcolm T Rutledge; Jurgen Bernhagen; Mark B Hampton; Sigurd M Wilbanks
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-08-29

4.  Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors.

Authors:  Yoonsang Cho; Jon J Vermeire; Jane S Merkel; Lin Leng; Xin Du; Richard Bucala; Michael Cappello; Elias Lolis
Journal:  Chem Biol       Date:  2011-09-23

5.  Ostertagia ostertagi macrophage migration inhibitory factor is present in all developmental stages and may cross-regulate host functions through interaction with the host receptor.

Authors:  Guanggang Qu; Raymond Fetterer; Lin Leng; Xin Du; Dante Zarlenga; Zhiqiang Shen; Wenyu Han; Richard Bucala; Wenbin Tuo
Journal:  Int J Parasitol       Date:  2014-02-28       Impact factor: 3.981

6.  Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor.

Authors:  D V Pastrana; N Raghavan; P FitzGerald; S W Eisinger; C Metz; R Bucala; R P Schleimer; C Bickel; A L Scott
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

7.  Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi.

Authors:  J L Pennock; J M Behnke; Q D Bickle; E Devaney; R K Grencis; R E Isaac; G W Joshua; M E Selkirk; Y Zhang; D J Meyer
Journal:  Biochem J       Date:  1998-11-01       Impact factor: 3.857

8.  A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation.

Authors:  Günter Fingerle-Rowson; Dayananda Rao Kaleswarapu; Corinna Schlander; Nazanin Kabgani; Tania Brocks; Nina Reinart; Raymonde Busch; Anke Schütz; Hongqi Lue; Xin Du; Aihua Liu; Huabao Xiong; Yibang Chen; Alice Nemajerova; Michael Hallek; Jürgen Bernhagen; Lin Leng; Richard Bucala
Journal:  Mol Cell Biol       Date:  2009-02-02       Impact factor: 4.272

9.  Structures of Leishmania major orthologues of macrophage migration inhibitory factor.

Authors:  Julia M Richardson; Lesley S Morrison; Nicholas D Bland; Sandra Bruce; Graham H Coombs; Jeremy C Mottram; Malcolm D Walkinshaw
Journal:  Biochem Biophys Res Commun       Date:  2009-01-31       Impact factor: 3.575

10.  The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei.

Authors:  Sarah E Dobson; Kevin D Augustijn; James A Brannigan; Claudia Schnick; Chris J Janse; Eleanor J Dodson; Andrew P Waters; Anthony J Wilkinson
Journal:  Protein Sci       Date:  2009-12       Impact factor: 6.725
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