Literature DB >> 8605021

Molecular cloning of a novel basic helix-loop-helix protein from the rat brain.

H Kume1, K Maruyama, T Tomita, T Iwatsubo, T C Saido, K Obata.   

Abstract

In the mammalian nervous system, several basic helix-loop-helix (bHLH) proteins have been identified that may play essential roles in neurogenesis or neural development. This paper describes a novel bHLH protein in rat brain, which has a bHLH domain highly homologous with that of MATH-2 and NeuroD. On the other hand, the amino-acid sequence of the other regions had little homology with those of the known proteins. This protein consists of 381 amino acids and was detected only in neural tissue, indicating that it has an important role specific to neuronal activities.

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Year:  1996        PMID： 8605021     DOI： 10.1006/bbrc.1996.0267

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Conversion of ectoderm into a neural fate by ATH-3, a vertebrate basic helix-loop-helix gene homologous to Drosophila proneural gene atonal.

Authors:  K Takebayashi; S Takahashi; C Yokota; H Tsuda; S Nakanishi; M Asashima; R Kageyama
Journal:  EMBO J       Date:  1997-01-15       Impact factor: 11.598

2.  Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice.

Authors:  F J Naya; H P Huang; Y Qiu; H Mutoh; F J DeMayo; A B Leiter; M J Tsai
Journal:  Genes Dev       Date:  1997-09-15       Impact factor: 11.361

3.  Identification of the C-terminal activation domain of the NeuroD-related factor (NDRF).

Authors:  Y Konishi; T Aoki; N Ohkawa; T Matsu-Ura; K Mikoshiba; T Tamura
Journal:  Nucleic Acids Res       Date:  2000-06-15       Impact factor: 16.971

4.  Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus.

Authors:  M H Schwab; A Bartholomae; B Heimrich; D Feldmeyer; S Druffel-Augustin; S Goebbels; F J Naya; S Zhao; M Frotscher; M J Tsai; K A Nave
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

5.  Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice.

Authors:  M H Schwab; S Druffel-Augustin; P Gass; M Jung; M Klugmann; A Bartholomae; M J Rossner; K A Nave
Journal:  J Neurosci       Date:  1998-02-15       Impact factor: 6.167

6.  NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.

Authors:  M B McCormick; R M Tamimi; L Snider; A Asakura; D Bergstrom; S J Tapscott
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

7.  NeuroD2 controls inhibitory circuit formation in the molecular layer of the cerebellum.

Authors:  Alexander Pieper; Stephanie Rudolph; Georg L Wieser; Tilmann Götze; Hendrik Mießner; Tomoko Yonemasu; Kuo Yan; Iva Tzvetanova; Bettina Duverge Castillo; Ulli Bode; Ingo Bormuth; Jacques I Wadiche; Markus H Schwab; Sandra Goebbels
Journal:  Sci Rep       Date:  2019-02-05       Impact factor: 4.379

Review 8.  Transcriptional regulatory network during development in the olfactory epithelium.

Authors:  SeungYeong Im; Cheil Moon
Journal:  BMB Rep       Date:  2015-11       Impact factor: 4.778
  8 in total

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