Literature DB >> 8603975

Disseminated Mycobacterium avium complex: correlation between blood and tissue burden.

F J Torriani1, C A Behling, J A McCutchan, R H Haubrich, D V Havlir.   

Abstract

To determine the relationship between levels of Mycobacterium avium complex (MAC) in blood and tissues, histopathologic examination and quantitative MAC cultures were done on blood samples and tissue samples of 7 organs at autopsy of 10 AIDS patients who had been treated for MAC bacteremia. Blood and tissue cultures were negative for MAC for 3 of the patients and positive for 7. The numbers of MAC colony-forming units in the blood and tissues were highly correlated. The highest concentrations of MAC were observed in the reticuloendothelial organs, with a maximum of 6.9 log10 cfu/g in mesenteric lymph nodes and 6.8 log10 cfu/g in spleen. Histopathologic findings paralleled quantitative cultures and were consistent with entry of MAC via lymphatics through the gastrointestinal tract, followed by hematogenous dissemination.

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Year:  1996        PMID： 8603975     DOI： 10.1093/infdis/173.4.942

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  8 in total

1.  Use of different molecular typing techniques for bacteriological follow-up in a clinical trial with AIDS patients with Mycobacterium avium bacteremia.

Authors:  M Picardeau; A Varnerot; T Lecompte; F Brel; T May; V Vincent
Journal:  J Clin Microbiol       Date:  1997-10       Impact factor: 5.948

2.  Activities of isoniazid alone and in combination with other drugs against Mycobacterium avium infection in beige mice.

Authors:  L Fattorini; Y Xiao; M Mattei; Y Li; E Iona; M L Ricci; O F Thoresen; R Creti; G Orefici
Journal:  Antimicrob Agents Chemother       Date:  1998-03       Impact factor: 5.191

3.  Moxifloxacin pharmacokinetics/pharmacodynamics and optimal dose and susceptibility breakpoint identification for treatment of disseminated Mycobacterium avium infection.

Authors:  Devyani Deshpande; Shashikant Srivastava; Claudia Meek; Richard Leff; Gerri S Hall; Tawanda Gumbo
Journal:  Antimicrob Agents Chemother       Date:  2010-04-12       Impact factor: 5.191

4.  Ethambutol optimal clinical dose and susceptibility breakpoint identification by use of a novel pharmacokinetic-pharmacodynamic model of disseminated intracellular Mycobacterium avium.

Authors:  Devyani Deshpande; Shashikant Srivastava; Claudia Meek; Richard Leff; Tawanda Gumbo
Journal:  Antimicrob Agents Chemother       Date:  2010-03-15       Impact factor: 5.191

5.  Pathogenesis of systemic Mycobacterium avium infection in pigs through histological analysis of hepatic lesions.

Authors:  Kenji Hibiya; Kimiko Utsunomiya; Takashi Yoshida; Satoshi Toma; Futoshi Higa; Masao Tateyama; Jiro Fujita
Journal:  Can J Vet Res       Date:  2010-10       Impact factor: 1.310

6.  The antibiotic resistance arrow of time: efflux pump induction is a general first step in the evolution of mycobacterial drug resistance.

Authors:  Aurelia M Schmalstieg; Shashikant Srivastava; Serkan Belkaya; Devyani Deshpande; Claudia Meek; Richard Leff; Nicolai S C van Oers; Tawanda Gumbo
Journal:  Antimicrob Agents Chemother       Date:  2012-07-02       Impact factor: 5.191

Review 7.  Disseminated mycobacterium avium-intracellulare complex (MAC) infection in the era of effective antiretroviral therapy: is prophylaxis still indicated?

Authors:  Christoph G Lange; Ian J Woolley; Reinhard H Brodt
Journal:  Drugs       Date:  2004       Impact factor: 9.546

Review 8.  Nontuberculous mycobacterial osteomyelitis.

Authors:  Sheng Bi; Fei-Shu Hu; Hai-Ying Yu; Kai-Jin Xu; Bei-Wen Zheng; Zhong-Kang Ji; Jun-Jie Li; Mei Deng; Hai-Yang Hu; Ji-Fang Sheng
Journal:  Infect Dis (Lond)       Date:  2015-04-27
  8 in total

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