| Literature DB >> 8603959 |
K Krawczynski1, M J Alter, D L Tankersley, M Beach, B H Robertson, S Lambert, G Kuo, J E Spelbring, E Meeks, S Sinha, D A Carson.
Abstract
The efficacy of postexposure prophylaxis for the prevention of hepatitis C virus (HCV) infection was studied in experimentally infected chimpanzees. Three chimpanzees were inoculated with HCV: Two were treated 1 h later with anti-HCV--negative intravenous immune globulin (IGIV) or hepatitis C immune globulin (HCIG), and a third animal was not treated. HCV infection was detected in all 3 animals within a few days of inoculation. Once passively transferred anti-HCV declined in the HCIG-treated animal, there was an increase of HCV antigen (Ag)--positive hepatocytes followed by reappearance of anti-HCV; HCV Ag disappeared concordant with the development of acute hepatitis. Acute hepatitis C developed in both the IGIV-treated and untreated chimpanzees, with peak liver enzyme activity on day 59, but was delayed in the HCIG-treated animal until day 146. Postexposure HCIG treatment markedly prolonged the incubation period of acute hepatitis C but did not prevent or delay HCV infection. IGIV had no effect on the course of HCV infection.Entities:
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Year: 1996 PMID： 8603959 DOI： 10.1093/infdis/173.4.822
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226