Literature DB >> 8603732

Inhibitor sensitivity of respiratory complex I in human platelets: a possible biomarker of ageing.

M Merlo Pich1, C Bovina, G Formiggini, G G Cometti, A Ghelli, G Parenti Castelli, M L Genova, M Marchetti, S Semeraro, G Lenaz.   

Abstract

NADH-Coenzyme Q reductase was assayed in platelet mitochondrial membranes obtained from 19 pools of two venous blood samples from female young (19-30 years) individuals and 18 pools from aged ones (66-107 years). The enzyme activities were not significantly changed in the two groups, but a decrease of sensitivity to the specific inhibitor, rotenone, occurred in a substantial number of aged individuals. The results are in agreement with the predictions of the mitochondrial theory of ageing and may be used to develop a sensitive biomarker of the ageing process.

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Year:  1996        PMID： 8603732     DOI： 10.1016/0014-5793(96)00037-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

Review 1.  Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease.

Authors:  L Holper; D Ben-Shachar; J J Mann
Journal:  Neuropsychopharmacology       Date:  2018-05-16       Impact factor: 7.853

2.  Mitochondrial complex I defects in aging.

Authors:  G Lenaz; C Bovina; C Castelluccio; R Fato; G Formiggini; M L Genova; M Marchetti; M M Pich; F Pallotti; G Parenti Castelli; G Biagini
Journal:  Mol Cell Biochem       Date:  1997-09       Impact factor: 3.396

3.  Loss of estrogen receptor beta decreases mitochondrial energetic potential and increases thrombogenicity of platelets in aged female mice.

Authors:  Muthuvel Jayachandran; Claudia C Preston; Larry W Hunter; Arshad Jahangir; Whyte G Owen; Kenneth S Korach; Virginia M Miller
Journal:  Age (Dordr)       Date:  2009-11-12

4.  Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice.

Authors:  Jie Xu; Chun Shi; Qi Li; Jiajia Wu; E Lucy Forster; David T Yew
Journal:  J Bioenerg Biomembr       Date:  2007-04-14       Impact factor: 3.853

5.  Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis.

Authors:  Fredrik Sjövall; Saori Morota; Magnus J Hansson; Hans Friberg; Erich Gnaiger; Eskil Elmér
Journal:  Crit Care       Date:  2010-11-24       Impact factor: 9.097

6.  Mitochondrial changes in platelets are not related to those in skeletal muscle during human septic shock.

Authors:  Alessandro Protti; Francesco Fortunato; Maria L Caspani; Mauro Pluderi; Valeria Lucchini; Nadia Grimoldi; Luigi P Solimeno; Gigliola Fagiolari; Patrizia Ciscato; Samis M A Zella; Maurizio Moggio; Giacomo P Comi; Luciano Gattinoni
Journal:  PLoS One       Date:  2014-05-01       Impact factor: 3.240

7.  A Multivariate Metabolomics Method for Estimating Platelet Mitochondrial Oxygen Consumption Rates in Patients with Sepsis.

Authors:  Marc R McCann; Cora E McHugh; Maggie Kirby; Theodore S Jennaro; Alan E Jones; Kathleen A Stringer; Michael A Puskarich
Journal:  Metabolites       Date:  2020-04-02

8.  Mitochondrial Respiration of Platelets: Comparison of Isolation Methods.

Authors:  Andrea Vernerova; Luiz Felipe Garcia-Souza; Ondrej Soucek; Milan Kostal; Vit Rehacek; Lenka Kujovska Krcmova; Erich Gnaiger; Ondrej Sobotka
Journal:  Biomedicines       Date:  2021-12-08
  8 in total

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