| Literature DB >> 8602240 |
C Rose1, F Vargas, P Facchinetti, P Bourgeat, R B Bambal, P B Bishop, S M Chan, A N Moore, C R Ganellin, J C Schwartz.
Abstract
A cholecystokinin (CCK)-inactivating peptidase was purified and identified as a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10), a cytosolic subtilisin-like peptidase of previously unknown functions. The peptidase was found in neurons responding to cholecystokinin, as well as in non-neuronal cells. Butabindide, a potent and specific inhibitor, was designed and shown to protect endogenous cholecystokinin from inactivation and to display pro-satiating effects mediated by the CCKA receptor.Entities:
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Year: 1996 PMID： 8602240 DOI： 10.1038/380403a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962