Literature DB >> 8601455

Identification of macrophage migration inhibitory factor (MIF) in human skin and its immmunohistochemical localization.

T Shimizu1, A Ohkawara, J Nishihira, W Sakamoto.   

Abstract

The presence and tissue localization of macrophage migration inhibitory factor (MIF) in human skin were examined. Reverse transcription-polymerase chain reaction analysis revealed that MIF mRNA was expressed in both surgically obtained normal human epidermis and primary cultured human keratinocytes. The expression of MIF was further confirmed by Western blot analysis, which demonstrated a single band at about 12.5 kDa using a polyclonal antibody against human recombinant MIF. Immunohistochemical studies showed that MIF existed in human epidermis, especially in the basal layer. The pathophysiological role of MIF in human skin remains undefined; however, the present results indicate that MIF may play an important role in immunity, inflammation and cellular differentiation of epidermal cells.

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Year:  1996        PMID： 8601455     DOI： 10.1016/0014-5793(96)00120-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

1.  Involvement of macrophage migration inhibitory factor (MIF) in the mechanism of tumor cell growth.

Authors:  N Takahashi; J Nishihira; Y Sato; M Kondo; H Ogawa; T Ohshima; Y Une; S Todo
Journal:  Mol Med       Date:  1998-11       Impact factor: 6.354

2.  Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice.

Authors:  T Ohkawara; H Takeda; J Nishihira; K Miyashita; M Nihiwaki; Y Ishiguro; K Takeda; S Akira; T Iwanaga; T Sugiyama; M Asaka
Journal:  Clin Exp Immunol       Date:  2005-09       Impact factor: 4.330

3.  Macrophage migration inhibitory factor induces phagocytosis of foreign particles by macrophages in autocrine and paracrine fashion.

Authors:  S Onodera; K Suzuki; T Matsuno; K Kaneda; M Takagi; J Nishihira
Journal:  Immunology       Date:  1997-09       Impact factor: 7.397

4.  Regulation of Toll-like receptor 4 expression in mouse colon by macrophage migration inhibitory factor.

Authors:  Tatsuya Ohkawara; Hiroshi Takeda; Kencho Miyashita; Morie Nishiwaki; Toshinori Nakayama; Masaru Taniguchi; Takashi Yoshiki; Junji Tanaka; Junji Takana; Masahiro Imamura; Toshiro Sugiyama; Masahiro Asaka; Jun Nishihira
Journal:  Histochem Cell Biol       Date:  2005-12-07       Impact factor: 4.304

5.  Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor.

Authors:  D V Pastrana; N Raghavan; P FitzGerald; S W Eisinger; C Metz; R Bucala; R P Schleimer; C Bickel; A L Scott
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

6.  Intratumoral expression of macrophage migration inhibitory factor is correlated with serum C-reactive protein and interleukin-6 in patients with non-small cell lung cancer.

Authors:  Motoharu Hamatake; Ichiro Yoshino; Makiko Tomiyasu; Naoko Miura; Hiroshi Okazaki; Taro Ohba; Tomohiro Takenaka; Yoshihiko Maehara
Journal:  Surg Today       Date:  2008-09-27       Impact factor: 2.549

7.  Immunohistochemical localization of macrophage migration inhibitory factor (MIF) in human gingival tissue and its pathophysiological functions.

Authors:  Tatsuya Morimoto; Jun Nishihira; Takao Kohgo
Journal:  Histochem Cell Biol       Date:  2003-09-09       Impact factor: 4.304

8.  Increased expression of macrophage migration inhibitory factor during fracture healing in rats.

Authors:  Shin Onodera; Jun Nishihira; Masashi Yamazaki; Teruo Ishibashi; Akio Minami
Journal:  Histochem Cell Biol       Date:  2004-02-06       Impact factor: 4.304

9.  Expression of macrophage migration inhibitory factor in diffuse systemic sclerosis.

Authors:  E Selvi; S A Tripodi; M Catenaccio; S Lorenzini; D Chindamo; S Manganelli; R Romagnoli; F Ietta; L Paulesu; C Miracco; M Cintorino; R Marcolongo
Journal:  Ann Rheum Dis       Date:  2003-05       Impact factor: 19.103

10.  Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74.

Authors:  Yoonsang Cho; Brian F Jones; Jon J Vermeire; Lin Leng; Lisa DiFedele; Lisa M Harrison; Huabao Xiong; Yuen-Kwan Amy Kwong; Yibang Chen; Richard Bucala; Elias Lolis; Michael Cappello
Journal:  J Biol Chem       Date:  2007-06-13       Impact factor: 5.157
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