Literature DB >> 8600515

Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein.

J M Ball1, P Tian, C Q Zeng, A P Morris, M K Estes.   

Abstract

The rotavirus nonstructural glycoprotein NSP4 is an intracellular receptor that mediates the acquisition of a transient membrane envelope as subviral particles bud into the endoplasmic reticulum. NSP4 also causes an increase in intracellular calcium in insect cells. Purified NSP4 or a peptide corresponding to NSP4 residues 114 to 135 induced diarrhea in young (6 to 10 days old) CD1 mice. This disease response was age-dependent, dose-dependent, and specific. Electrophysiologic data from intestinal mucosa showed that the NSP4 114-135 peptide potentiates chloride secretion by a calcium-dependent signaling pathway. Diarrhea is induced when NSP4, acting as a viral enterotoxin, triggers a signal transduction pathway.

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Year:  1996        PMID： 8600515     DOI： 10.1126/science.272.5258.101

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  208 in total

1.  Probing the structure of rotavirus NSP4: a short sequence at the extreme C terminus mediates binding to the inner capsid particle.

Authors:  J A O'Brien; J A Taylor; A R Bellamy
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

2.  Is prolonged rotavirus infection a common cause of protracted diarrhoea?

Authors:  M Sood; I W Booth
Journal:  Arch Dis Child       Date:  1999-04       Impact factor: 3.791

3.  A functional NSP4 enterotoxin peptide secreted from rotavirus-infected cells.

Authors:  M Zhang; C Q Zeng; A P Morris; M K Estes
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

4.  Differential infection of polarized epithelial cell lines by sialic acid-dependent and sialic acid-independent rotavirus strains.

Authors:  M Ciarlet; S E Crawford; M K Estes
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

5.  Trypsin cleavage stabilizes the rotavirus VP4 spike.

Authors:  S E Crawford; S K Mukherjee; M K Estes; J A Lawton; A L Shaw; R F Ramig; B V Prasad
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

6.  Diarrhea-inducing activity of avian rotavirus NSP4 glycoproteins, which differ greatly from mammalian rotavirus NSP4 glycoproteins in deduced amino acid sequence in suckling mice.

Authors:  Yoshio Mori; Mohammed Ali Borgan; Naoto Ito; Makoto Sugiyama; Nobuyuki Minamoto
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

Review 7.  Why should a clinician care about the molecular biology of transport?

Authors:  A J Janecki
Journal:  Curr Gastroenterol Rep       Date:  2000-10

Review 8.  Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation.

Authors:  J Berkes; V K Viswanathan; S D Savkovic; G Hecht
Journal:  Gut       Date:  2003-03       Impact factor: 23.059

9.  Attenuation of a human rotavirus vaccine candidate did not correlate with mutations in the NSP4 protein gene.

Authors:  R L Ward; B B Mason; D I Bernstein; D S Sander; V E Smith; G A Zandle; R S Rappaport
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

10.  Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.

Authors:  Benyue Zhang; Benoit Chassaing; Zhenda Shi; Robin Uchiyama; Zhan Zhang; Timothy L Denning; Sue E Crawford; Andrea J Pruijssers; Jason A Iskarpatyoti; Mary K Estes; Terence S Dermody; Wenjun Ouyang; Ifor R Williams; Matam Vijay-Kumar; Andrew T Gewirtz
Journal:  Science       Date:  2014-11-14       Impact factor: 47.728
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