Literature DB >> 8599331

Genetic modification of milk proteins.

A J Clark1.   

Abstract

It is now possible to change the protein composition of milk by direct manipulation of the germline. At present it is feasible only to add new milk-protein genes to dairy animals. If embryonic stem cells become available then it will also be possible to remove or replace endogenous genes. Various modifications made to milk proteins by using these germline-manipulation techniques are described. These are expected to enhance the processing, nutritional, and biomedical properties of milk.

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Year:  1996        PMID： 8599331     DOI： 10.1093/ajcn/63.4.633

Source DB:  PubMed          Journal:  Am J Clin Nutr        ISSN： 0002-9165            Impact factor:   7.045


  6 in total

Review 1.  Biomedical and agricultural applications of animal transgenesis.

Authors:  Alison J Thomson; Jim McWhir
Journal:  Mol Biotechnol       Date:  2004-07       Impact factor: 2.695

2.  Introduction of a proximal Stat5 site in the murine alpha-lactalbumin promoter induces prolactin dependency in vitro and improves expression frequency in vivo.

Authors:  S Soulier; L Lepourry; M G Stinnakre; B Langley; P J L'Huillier; J Paly; J Djiane; J C Mercier; J L Vilotte
Journal:  Transgenic Res       Date:  1999-02       Impact factor: 2.788

3.  Over-expression of the murine pIgR gene in the mammary gland of transgenic mice influences the milk composition and reduces its nutritional value.

Authors:  N de Groot; P van Kuik-Romeijn; S H Lee; H A de Boer
Journal:  Transgenic Res       Date:  2001-08       Impact factor: 2.788

4.  Position-independent and copy-number-related expression of a goat bacterial artificial chromosome alpha-lactalbumin gene in transgenic mice.

Authors:  M G Stinnakre; S Soulier; L Schibler; L Lepourry; J C Mercier; J L Vilotte
Journal:  Biochem J       Date:  1999-04-01       Impact factor: 3.857

5.  Ectopic expression of tethered human follicle-stimulating hormone (hFSH) gene in transgenic mice.

Authors:  Myoung Ok Kim; Sung Hyun Kim; Sang Ryeul Lee; Mi Jung Shin; Kwan Sik Min; Dong Beom Lee; Sung Won Lee; Kil Soo Kim; Sun Jung Kim; Zae Young Ryoo
Journal:  Transgenic Res       Date:  2006-11-11       Impact factor: 2.788

6.  Expression of lysostaphin in milk of transgenic mice affects the growth of neonates.

Authors:  Abhijit Mitra; Kathleen S Hruska; Olga Wellnitz; David E Kerr; Anthony V Capuco; Robert J Wall
Journal:  Transgenic Res       Date:  2003-10       Impact factor: 2.788
  6 in total

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