Literature DB >> 8596934

Induction of TH1 and TH2 immunity in neonatal mice.

T Forsthuber1, H C Yip, P V Lehmann.   

Abstract

The neonatal period has been thought of as a window in ontogeny, during which the developing immune system is particularly susceptible to tolerization. In the present study, the classic system for induction of neonatal tolerance to protein antigens was reexamined in mice. The presumably tolerogenic protocol was found to trigger a vigorous T helper cell type 2 (TH2) immune response. Thus, neonatal "tolerization" induces immune deviation, not tolerance in the immunological sense. Neonates are not immune privileged but generate TH2 or TH1 responses, depending on the mode of immunization.

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Year:  1996        PMID： 8596934     DOI： 10.1126/science.271.5256.1728

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  149 in total

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