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Literature DB >> 8595930

Effects of interferon-gamma on cell differentiation and cytokine production of a human monoblast cell line, U937.

T Ishizuka¹, I Hirata, M Adachi, F Kurimoto, T Hisada, K Dobashi, M Mori.

Abstract

The U937 cell, a human monoblast cell line, has been used as a model to study the function of human monocytes. We investigated the effects of interferon-gamma (IFN-gamma) on superoxide anion (O2-) production, cell surface antigens, and cytokine production of U937 cells. IFN-gamma treatment enhanced O2- production of fMLP or PMA-stimulated U937 cells. IFN-gamma increased the ratio of CD23 and CD11b positive cells. The fluorescence intensity of CD14 and CD25 was enhanced by IFN-gamma treatment. U937 cells produced IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha by lipopolysaccharide (LPS) stimulation. IFN-gamma treatment enhanced TNF-alpha production, but decreased IL-6 production. These results suggest that IFN-gamma differentiates U937 cells to monocyte-like cells and it regulates the production systems of IL-6 and TNF-alpha separately in U937 cells.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1995 PMID： 8595930 DOI： 10.1007/bf01534567

Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092

27 in total

1. Interferon gamma drastically modifies the regulation of interleukin 1 genes by endotoxin in U937 cells.

Authors: C Ucla; P Roux-Lombard; S Fey; J M Dayer; B Mach
Journal: J Clin Invest Date: 1990-01 Impact factor: 14.808

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Authors: D Aderka; J M Le; J Vilcek
Journal: J Immunol Date: 1989-12-01 Impact factor: 5.422

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Authors: T M Schepers; J B Klein; P W Feldhoff; W L Dean; K R McLeish
Journal: J Interferon Res Date: 1992-08

6. Regulation of TNF-alpha, IL-1 and IL-6 synthesis in differentiating human monoblastoid leukemic U937 cells.

Authors: R Hass; G Lonnemann; D Männel; N Topley; A Hartmann; L Köhler; K Resch; M Goppelt-Strübe
Journal: Leuk Res Date: 1991 Impact factor: 3.156

7. Synergism of interleukin 6 and 1 alpha,25-dihydroxyvitamin D3 in induction of myeloid differentiation of human leukemic cell lines.

Authors: A J Duits; W Dimjati; J G van de Winkel; P J Capel
Journal: J Leukoc Biol Date: 1992-03 Impact factor: 4.962

1. Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators.

Authors: J An; R C Ribeiro; P Webb; J A Gustafsson; P J Kushner; J D Baxter; D C Leitman
Journal: Proc Natl Acad Sci U S A Date: 1999-12-21 Impact factor: 11.205

1 in total