Literature DB >> 8595170

Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: a prospective analysis.

F Janot1, J Klijanienko, A Russo, J P Mamet, F de Braud, A K El-Naggar, J P Pignon, B Luboinski, E Cvitkovic.   

Abstract

The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation, tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on the overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.

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Year:  1996        PMID： 8595170      PMCID： PMC2074448          DOI： 10.1038/bjc.1996.92

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  25 in total

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Authors:  J Klijanienko; A K el-Naggar; F de Braud; J L Rodriguez-Peralto; R Rodriguez; M Itzhaki; A Russo; F Janot; B Luboinski; E Cvitkovic
Journal:  Cancer       Date:  1995-04-01       Impact factor: 6.860

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Journal:  Cancer       Date:  1986-02-15       Impact factor: 6.860

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Journal:  Cancer       Date:  1989-04-15       Impact factor: 6.860

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Journal:  Cancer       Date:  1984-12-15       Impact factor: 6.860

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  19 in total

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Journal:  Am J Pathol       Date:  2001-11       Impact factor: 4.307

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Authors:  Silke Wemmert; Maximilian Linxweiler; Cornelia Lerner; Florian Bochen; Philipp Kulas; Johannes Linxweiler; Sigrun Smola; Steffi Urbschat; Stefan Wagenpfeil; Bernhard Schick
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Authors:  S Kantola; K Jokinen; K Hyrynkangas; P Mäntyselkä; O P Alho
Journal:  Br J Gen Pract       Date:  2001-02       Impact factor: 5.386

Review 6.  The clinical relevance of Ki-67 expression in laryngeal squamous cell carcinoma.

Authors:  Federico Maria Gioacchini; Matteo Alicandri-Ciufelli; Giuseppe Magliulo; Corrado Rubini; Livio Presutti; Massimo Re
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Authors:  Eben L Rosenthal; Lynn M Matrisian
Journal:  Head Neck       Date:  2006-07       Impact factor: 3.147

8.  Cytokeratin 8/18 expression indicates a poor prognosis in squamous cell carcinomas of the oral cavity.

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Journal:  BMC Cancer       Date:  2006-01-13       Impact factor: 4.430

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Journal:  Br J Cancer       Date:  1998-06       Impact factor: 7.640
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