M A Sandberg1, A R Gaudio. 1. Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114, USA.
Abstract
PURPOSE: To determine whether photostress recovery time varies with severity of disease in age-related macular degeneration. METHODS: Photostress recovery time, visual acuity, and foveal retinal pigment epithelial atrophy were evaluated for the fellow eyes of 133 patients with unilateral neovascular age-related macular degeneration. Recovery times were measured by a method that flashed letters on a computer screen in random order before and after a 10 second bleach. RESULTS: Recovery times were delayed in 62% of the patients (including 47% of those with normal visual acuity), ranged up to 6 times the normal limit, and increased with advancing age (P < 0.0001). Photostress recovery time was inversely correlated with visual acuity (P < 0.0001) and longer in eyes with visible atrophy than in eyes without atrophy (P = 0.0007). Significant relationships between these two pairs of measures were also found after controlling for age. CONCLUSION: These findings support previous evidence that the time for visual recovery after exposure to a glare source is commonly slowed in age-related macular degeneration even among patients with normal visual acuity and further show that it can vary with age and extent of disease.
PURPOSE: To determine whether photostress recovery time varies with severity of disease in age-related macular degeneration. METHODS: Photostress recovery time, visual acuity, and foveal retinal pigment epithelial atrophy were evaluated for the fellow eyes of 133 patients with unilateral neovascular age-related macular degeneration. Recovery times were measured by a method that flashed letters on a computer screen in random order before and after a 10 second bleach. RESULTS: Recovery times were delayed in 62% of the patients (including 47% of those with normal visual acuity), ranged up to 6 times the normal limit, and increased with advancing age (P < 0.0001). Photostress recovery time was inversely correlated with visual acuity (P < 0.0001) and longer in eyes with visible atrophy than in eyes without atrophy (P = 0.0007). Significant relationships between these two pairs of measures were also found after controlling for age. CONCLUSION: These findings support previous evidence that the time for visual recovery after exposure to a glare source is commonly slowed in age-related macular degeneration even among patients with normal visual acuity and further show that it can vary with age and extent of disease.
Authors: Stephen A Burns; Ann E Elsner; Mariane B Mellem-Kairala; Ruthanne B Simmons Journal: Invest Ophthalmol Vis Sci Date: 2003-09 Impact factor: 4.799
Authors: Sarah Sabour-Pickett; James Loughman; John M Nolan; Jim Stack; Konrad Pesudovs; Katherine A Meagher; Stephen Beatty Journal: J Ophthalmol Date: 2013-02-21 Impact factor: 1.909