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Literature DB >> 8592645

Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy.

J Mao¹, D D Price, L L Phillips, J Lu, D J Mayer.

Abstract

Eight days after chronic constrictive sciatic nerve injury (CCI), protein kinase C gamma (PKC gamma) immunoreactivity reliably increased in the spinal cord dorsal horn of CCI rats with demonstrable thermal hyperalgesia as compared to sham-operated controls. Such PKC gamma immunostaining was observed primarily in neuronal somata (ipsilateral > contralateral, laminae I-II > III-IV), indicating postsynaptic sites of PKC gamma increases. Both the development of thermal hyperalgesia and the increase in PKC gamma immunoreactivity in CCI rats were prevented by once daily intrathecal administration with 10 nmol MK-801 for 7 days. The present results provide further evidence for a role of PKC in N-methyl-D-aspartate (NMDA) receptor-mediated mechanisms of thermal hyperalgesia.

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Year: 1995 PMID： 8592645 DOI： 10.1016/0304-3940(95)11975-3

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

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Cited

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Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy.

Review 1. New treatments for chronic prostatitis/chronic pelvic pain syndrome.

2. Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats.

Review 3. PKCγ interneurons, a gateway to pathological pain in the dorsal horn.

4. Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons.

Review 5. Glutamate receptors and nociception: implications for the drug treatment of pain.

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10. Effects on Spatial Cognition and Nociceptive Behavior Following Peripheral Nerve Injury in Rats with Lesion of the Striatal Marginal Division Induced by Kainic Acid.