Literature DB >> 8592468

MtDNA-encoded histocompatibility antigens.

V M Dabhi1, K F Lindahl.   

Abstract

Mitochondrially encoded H antigens are by-products of a system that has evolved in vertebrates to present peptides from intracellular pathogens on the cell surface for detection by CTLs, which can lyse the infected cell. CTL lines and clones with defined specificity against mitochondrial H antigens, which can be maintained in culture for long periods, offer a unique tool in mitochondrial genetics. Expression of polymorphic mitochondrial H antigens depends on both the presence and the activity of the corresponding mitochondrial genome, and CTLs can provide strong selection against cells displaying their cognate antigen.

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Year:  1995        PMID： 8592468     DOI： 10.1016/0076-6879(95)60159-7

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  7 in total

1.  Mutations affecting a yeast mitochondrial inner membrane protein, pnt1p, block export of a mitochondrially synthesized fusion protein from the matrix.

Authors:  S He; T D Fox
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

2.  Induction of M3-restricted cytotoxic T lymphocyte responses by N-formylated peptides derived from Mycobacterium tuberculosis.

Authors:  T Chun; N V Serbina; D Nolt; B Wang; N M Chiu; J L Flynn; C R Wang
Journal:  J Exp Med       Date:  2001-05-21       Impact factor: 14.307

3.  The majority of H2-M3 is retained intracellularly in a peptide-receptive state and traffics to the cell surface in the presence of N-formylated peptides.

Authors:  N M Chiu; T Chun; M Fay; M Mandal; C R Wang
Journal:  J Exp Med       Date:  1999-08-02       Impact factor: 14.307

4.  The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus.

Authors:  N M Chiu; B Wang; K M Kerksiek; R Kurlander; E G Pamer; C R Wang
Journal:  J Exp Med       Date:  1999-12-20       Impact factor: 14.307

5.  Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides.

Authors:  Arne Strand; San-Tai Shen; Diana R Tomchick; Junmei Wang; Chyung-Ru Wang; Johann Deisenhofer
Journal:  J Biomol Struct Dyn       Date:  2021-06-28

Review 6.  Human embryonic stem cells: preclinical perspectives.

Authors:  Kaushik Dilip Deb; Kanchan Sarda
Journal:  J Transl Med       Date:  2008-01-29       Impact factor: 5.531

Review 7.  Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutations.

Authors:  Gerald Pfeffer; Ailbhe Burke; Patrick Yu-Wai-Man; D Alastair S Compston; Patrick F Chinnery
Journal:  Neurology       Date:  2013-11-06       Impact factor: 9.910
  7 in total

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