Literature DB >> 8591024

Bound to activate: conformational consequences of cyclin binding to CDK2.

E Radzio-Andzelm1, J Lew, S Taylor.   

Abstract

The cyclin-dependent kinases (CDKs) are among the most highly regulated enzymes in the protein-kinase family. The crystal structures of cyclin A and the CDK2-cyclin A complex spectacularly reveal the atomic basis for regulation of these enzymes and provide a template for understanding the function and regulation of other members of the CDK family.

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Year:  1995        PMID： 8591024     DOI： 10.1016/s0969-2126(01)00249-0

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  6 in total

1.  Importance of the A-helix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface.

Authors:  F W Herberg; B Zimmermann; M McGlone; S S Taylor
Journal:  Protein Sci       Date:  1997-03       Impact factor: 6.725

2.  Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.

Authors:  Zhao Qin Bao; Douglas M Jacobsen; Matthew A Young
Journal:  Structure       Date:  2011-05-11       Impact factor: 5.006

3.  Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer.

Authors:  Colin P Kenyon; Robyn L Roth; Chris W van der Westhuyzen; Christopher J Parkinson
Journal:  BMC Res Notes       Date:  2012-03-08

4.  Molecular basis of differential selectivity of cyclobutyl-substituted imidazole inhibitors against CDKs: insights for rational drug design.

Authors:  Soumya Lipsa Rath; Sanjib Senapati
Journal:  PLoS One       Date:  2013-09-13       Impact factor: 3.240

5.  Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Kinase 2.

Authors:  Jenny Gu; Philip E Bourne
Journal:  BMC Bioinformatics       Date:  2007-02-07       Impact factor: 3.169

6.  Mechanism of p27 Unfolding for CDK2 Reactivation.

Authors:  Soumya Lipsa Rath; Sanjib Senapati
Journal:  Sci Rep       Date:  2016-05-23       Impact factor: 4.379
  6 in total

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