Literature DB >> 8589680

Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3.

M Stack1, D Jones, G White, D S Liscia, T Venesio, G Casey, D Crichton, J Varley, E Mitchell, J Heighway.   

Abstract

The chromosome region 17p13.3 is thought to encode a tumour suppressor gene involved in sporadic breast cancer and other malignancies. Physical ordering of markers has been carried out by a series of multicolour fluorescent in situ hybridisation (FISH) experiments, using isolated yeast artificial chromosomes (YACs) and cosmids. Eight polymorphic markers ordered within this new physical map and one external marker were used to investigate the pattern of loss of heterozygosity in a panel of 40 sporadic breast tumour patients. The data revealed a region of high loss (60%) within distal 17p13.3, defined by markers D17S926, D17S695 and D17S849 which mapped close together. A contig of YACs was constructed physically linking these three markers.

Entities:  

Mesh：

Year:  1995        PMID： 8589680     DOI： 10.1093/hmg/4.11.2047

Source DB:  PubMed          Journal:  Hum Mol Genet        ISSN： 0964-6906            Impact factor:   6.150


  11 in total

1.  Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.

Authors:  Carlos Cardoso; Richard J Leventer; Heather L Ward; Kazuhito Toyo-Oka; June Chung; Alyssa Gross; Christa L Martin; Judith Allanson; Daniela T Pilz; Ann H Olney; Osvaldo M Mutchinick; Shinji Hirotsune; Anthony Wynshaw-Boris; William B Dobyns; David H Ledbetter
Journal:  Am J Hum Genet       Date:  2003-03-05       Impact factor: 11.025

2.  Genetic analysis using genomic representations.

Authors:  R Lucito; M Nakimura; J A West; Y Han; K Chin; K Jensen; R McCombie; J W Gray; M Wigler
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-14       Impact factor: 11.205

3.  Allelic imbalance at chromosome 17p13.3 (YNZ22) in breast cancer is independent of p53 mutation or p53 overexpression and is associated with poor prognosis at medium-term follow-up.

Authors:  A M Thompson; D N Crichton; R A Elton; M F Clay; U Chetty; C M Steel
Journal:  Br J Cancer       Date:  1998-03       Impact factor: 7.640

4.  Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.

Authors:  K E Munn; R A Walker; L Menasce; J M Varley
Journal:  Br J Cancer       Date:  1996-11       Impact factor: 7.640

5.  Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.

Authors:  G Meroni; A Reymond; M Alcalay; G Borsani; A Tanigami; R Tonlorenzi; C Lo Nigro; S Messali; M Zollo; D H Ledbetter; R Brent; A Ballabio; R Carrozzo
Journal:  EMBO J       Date:  1997-05-15       Impact factor: 11.598

6.  Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1.

Authors:  J Janke; K Schlüter; B Jandrig; M Theile; K Kölble; W Arnold; E Grinstein; A Schwartz; L Estevéz-Schwarz; P M Schlag; B M Jockusch; S Scherneck
Journal:  J Exp Med       Date:  2000-05-15       Impact factor: 14.307

7.  Allele loss from large regions of chromosome 17 is common only in certain histological subtypes of ovarian carcinomas.

Authors:  J Papp; B Csokay; P Bosze; Z Zalay; J Toth; B Ponder; E Olah
Journal:  Br J Cancer       Date:  1996-11       Impact factor: 7.640

8.  Prognostic significance of loss of heterozygosity at loci on chromosome 17p13.3-ter in sporadic breast cancer is evidence for a putative tumour suppressor gene.

Authors:  D S Liscia; R Morizio; T Venesio; C Palenzona; M Donadio; R Callahan
Journal:  Br J Cancer       Date:  1999-05       Impact factor: 7.640

9.  Expression of the Hypermethylated in Cancer gene (HIC-1) is associated with good outcome in human breast cancer.

Authors:  G Nicoll; D N Crichton; H E McDowell; N Kernohan; T R Hupp; A M Thompson
Journal:  Br J Cancer       Date:  2001-12-14       Impact factor: 7.640

10.  High levels of loss at the 17p telomere suggest the close proximity of a tumour suppressor.

Authors:  G R White; M Stack; M Santibáñez-Koref; D S Liscia; T Venesio; J C Wang; C Helms; H Donis-Keller; D C Betticher; H J Altermatt; P R Hoban; J Heighway
Journal:  Br J Cancer       Date:  1996-09       Impact factor: 7.640
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.