BACKGROUND: Cutaneous aging is due to intrinsic and extrinsic factors. While the pathologic hallmark of extrinsic aging (photoaging) is solar elastosis, intrinsic aging lacks any specific feature. Only a progressive thinning and loss of the dermal elastic network occasionally associated with focal thickening of the collagen bundles may be observed. In contrast to the different clinical patterns of solar elastosis, only one distinctive disorder has been related so far to intrinsic aging: the temporary wrinkles. OBJECTIVE: Pseudoxanthoma-elasticum-like papillary dermal elastolysis (PDE) and white fibrous papulosis of the neck (WFP) are further clincopathologic patterns of intrinsic aging. MATERIAL AND METHODS: Review of the literature and clinical and histologic studies of patients of our files. RESULTS: PDE and WFP share some peculiar clinical and histologic features, namely their occurrence in late adulthood and thinning or loss of the elastic fibers, mainly in the papillary dermis. Moreover, elastolysis in PDE and focal fibrosis in WFP, along with the abnormal elastic fibers, immature elastogenesis and activation of fibroblasts observed in PDE, are quite similar to the changes described in intrinsic aging. CONCLUSIONS: PDE and WFP along with temporary wrinkles and some cases of noninflammatory middermal elastolysis could be classified as 'age-related fibroelastolytic syndromes'.
BACKGROUND: Cutaneous aging is due to intrinsic and extrinsic factors. While the pathologic hallmark of extrinsic aging (photoaging) is solar elastosis, intrinsic aging lacks any specific feature. Only a progressive thinning and loss of the dermal elastic network occasionally associated with focal thickening of the collagen bundles may be observed. In contrast to the different clinical patterns of solar elastosis, only one distinctive disorder has been related so far to intrinsic aging: the temporary wrinkles. OBJECTIVE: Pseudoxanthoma-elasticum-like papillary dermal elastolysis (PDE) and white fibrous papulosis of the neck (WFP) are further clincopathologic patterns of intrinsic aging. MATERIAL AND METHODS: Review of the literature and clinical and histologic studies of patients of our files. RESULTS: PDE and WFP share some peculiar clinical and histologic features, namely their occurrence in late adulthood and thinning or loss of the elastic fibers, mainly in the papillary dermis. Moreover, elastolysis in PDE and focal fibrosis in WFP, along with the abnormal elastic fibers, immature elastogenesis and activation of fibroblasts observed in PDE, are quite similar to the changes described in intrinsic aging. CONCLUSIONS: PDE and WFP along with temporary wrinkles and some cases of noninflammatory middermal elastolysis could be classified as 'age-related fibroelastolytic syndromes'.
Authors: Young Chan Song; Byung Ho Oh; Jong Hyun Ko; Ji Young Kim; Young Ji Hwang; Yang Won Lee; Yong Beom Choe; Kyu Joong Ahn; Kyae Yong Song Journal: Ann Dermatol Date: 2011-05-27 Impact factor: 1.444
Authors: Kamal Akhtar; Thomas J Broekelmann; Ming Miao; Fred W Keeley; Barry C Starcher; Richard A Pierce; Robert P Mecham; Tracy L Adair-Kirk Journal: J Biol Chem Date: 2010-09-16 Impact factor: 5.157
Authors: Kamal Akhtar; Thomas J Broekelmann; Haowei Song; John Turk; Tom J Brett; Robert P Mecham; Tracy L Adair-Kirk Journal: J Biol Chem Date: 2011-02-14 Impact factor: 5.157
Authors: Lu Yin; Maressa C Criscito; Evan Stokar; Despina Siolas; Adele Haimovic; Kristen Lo Sicco; Nooshin K Brinster Journal: Am J Dermatopathol Date: 2021-10-01 Impact factor: 1.319
Authors: Evgeny A Shirshin; Yury I Gurfinkel; Alexander V Priezzhev; Victor V Fadeev; Juergen Lademann; Maxim E Darvin Journal: Sci Rep Date: 2017-04-26 Impact factor: 4.379