Literature DB >> 8588861

Ondansetron hydrochloride: a competitive serotonin 5-HT3 receptor blocker.

K C Mohan1, K Ravikumar.   

Abstract

The methyl substituted imidazole ring in the title compound, 2-methyl-1-(9-methyl-4-oxo-2,3,4,9-tetrahydro-1H-carbazol-3-yl) imidazol-3-ium chloride dihydrate, C18H20N3O+.Cl-.2H2O, is approximately perpendicular to the carbazole plane [dihedral angle 87.0(1) degrees]. The water molecules are involved in an elaborate network of hydrogen bonds that reinforce the stability of the dihydrate and the cohesion of the structure.

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Year:  1995        PMID: 8588861

Source DB:  PubMed          Journal:  Acta Crystallogr C        ISSN: 0108-2701            Impact factor:   1.172


  4 in total

1.  Compatibility and Physical Properties of Dexamethasone-Ondansetron Intravenous Admixture.

Authors:  Krit Suknuntha; Kotchakorn Wattanapoka; Pilor Poonpattanachai; Natanan Titipornwanich; Warunsuda Sripakdee
Journal:  Hosp Pharm       Date:  2022-03-02

2.  Development and evaluation of buccal bioadhesive tablet of an anti-emetic agent ondansetron.

Authors:  Nisreen Hassan; R K Khar; Mushir Ali; Javed Ali
Journal:  AAPS PharmSciTech       Date:  2009-09-09       Impact factor: 3.246

Review 3.  A clinical perspective on mucoadhesive buccal drug delivery systems.

Authors:  Ritu M Gilhotra; Mohd Ikram; Sunny Srivastava; Neeraj Gilhotra
Journal:  J Biomed Res       Date:  2013-06-06

4.  Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons.

Authors:  Zhenhua Jin; Goeun Lee; Sojin Kim; Cheung-Seog Park; Yong Seek Park; Young-Ho Jin
Journal:  Korean J Physiol Pharmacol       Date:  2014-04-03       Impact factor: 2.016

  4 in total

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