Literature DB >> 8588739

Molecular mechanisms of endotoxin activity.

J Schletter1, H Heine, A J Ulmer, E T Rietschel.   

Abstract

Endotoxin (lipopolysaccharide, LPS), a constituent of the outer membrane of the cell wall of gram-negative bacteria, exerts a wide variety of biological effects in humans. This review focuses on the molecular mechanisms underlying these activities and discusses structure-function relationships of the endotoxin molecule, its interaction with humoral and cellular receptors involved in cell activation, and transmembrane and intracellular signal transduction pathways.

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Year:  1995        PMID： 8588739     DOI： 10.1007/bf02529735

Source DB:  PubMed          Journal:  Arch Microbiol        ISSN： 0302-8933            Impact factor:   2.552


  43 in total

Review 1.  Lipopolysaccharide receptors and signal transduction pathways in mononuclear phagocytes.

Authors:  T Y Chen; M G Lei; T Suzuki; D C Morrison
Journal:  Curr Top Microbiol Immunol       Date:  1992       Impact factor: 4.291

2.  Cytokine induction by lipopolysaccharide (LPS) corresponds to lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS.

Authors:  H Loppnow; P Libby; M Freudenberg; J H Krauss; J Weckesser; H Mayer
Journal:  Infect Immun       Date:  1990-11       Impact factor: 3.441

Review 3.  Signal transduction via the MAP kinases: proceed at your own RSK.

Authors:  J Blenis
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

4.  Influence of the supramolecular structure of free lipid A on its biological activity.

Authors:  K Brandenburg; H Mayer; M H Koch; J Weckesser; E T Rietschel; U Seydel
Journal:  Eur J Biochem       Date:  1993-12-01

5.  A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells.

Authors:  J Han; J D Lee; L Bibbs; R J Ulevitch
Journal:  Science       Date:  1994-08-05       Impact factor: 47.728

Review 6.  Recognition of endotoxin by cells leading to transmembrane signaling.

Authors:  R J Ulevitch; P S Tobias
Journal:  Curr Opin Immunol       Date:  1994-02       Impact factor: 7.486

7.  Identification of a lipopolysaccharide binding domain in CD14 between amino acids 57 and 64.

Authors:  T S Juan; E Hailman; M J Kelley; L A Busse; E Davy; C J Empig; L O Narhi; S D Wright; H S Lichenstein
Journal:  J Biol Chem       Date:  1995-03-10       Impact factor: 5.157

8.  Enzymatically deacylated lipopolysaccharide (LPS) can antagonize LPS at multiple sites in the LPS recognition pathway.

Authors:  R L Kitchens; R S Munford
Journal:  J Biol Chem       Date:  1995-04-28       Impact factor: 5.157

9.  IL-1 induction-capacity of defined lipopolysaccharide partial structures.

Authors:  H Loppnow; H Brade; I Dürrbaum; C A Dinarello; S Kusumoto; E T Rietschel; H D Flad
Journal:  J Immunol       Date:  1989-05-01       Impact factor: 5.422

10.  Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.

Authors:  E Hailman; H S Lichenstein; M M Wurfel; D S Miller; D A Johnson; M Kelley; L A Busse; M M Zukowski; S D Wright
Journal:  J Exp Med       Date:  1994-01-01       Impact factor: 14.307
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  79 in total

Review 1.  The biology of endotoxin.

Authors:  H Heine; E T Rietschel; A J Ulmer
Journal:  Mol Biotechnol       Date:  2001-11       Impact factor: 2.695

2.  Modulation of CD14 and TLR4·MD-2 activities by a synthetic lipid A mimetic.

Authors:  Roberto Cighetti; Carlotta Ciaramelli; Stefania Enza Sestito; Ivan Zanoni; Łukasz Kubik; Ana Ardá-Freire; Valentina Calabrese; Francesca Granucci; Roman Jerala; Sonsoles Martín-Santamaría; Jesus Jiménez-Barbero; Francesco Peri
Journal:  Chembiochem       Date:  2013-12-12       Impact factor: 3.164

3.  Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.

Authors:  Umeharu Ohto; Koichi Fukase; Kensuke Miyake; Toshiyuki Shimizu
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-24       Impact factor: 11.205

4.  Pathogenicity of Bacteria Contaminating Blood Products.

Authors:  Sören G Gatermann
Journal:  Transfus Med Hemother       Date:  2011-07-12       Impact factor: 3.747

5.  Endotoxin stimulates liver macrophages to release mediators that inhibit an early step in hepadnavirus replication.

Authors:  U Klöcker; U Schultz; H Schaller; U Protzer
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

6.  Differential regulation of gap junctions by proinflammatory mediators in vitro.

Authors:  J Hu; I A Cotgreave
Journal:  J Clin Invest       Date:  1997-05-15       Impact factor: 14.808

7.  Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids.

Authors:  Ryan G Snodgrass; Shurong Huang; Il-Whan Choi; John C Rutledge; Daniel H Hwang
Journal:  J Immunol       Date:  2013-09-16       Impact factor: 5.422

8.  Endotoxin-induced endothelial fibrosis is dependent on expression of transforming growth factors β1 and β2.

Authors:  César Echeverría; Ignacio Montorfano; Pablo Tapia; Claudia Riedel; Claudio Cabello-Verrugio; Felipe Simon
Journal:  Infect Immun       Date:  2014-06-16       Impact factor: 3.441

9.  Regulation and functional impact of lipopolysaccharide induced Nod2 gene expression in the murine epididymal epithelial cell line PC1.

Authors:  Marcus Mühlbauer; Adam W Cheely; Suresh Yenugu; Christian Jobin
Journal:  Immunology       Date:  2008-02-12       Impact factor: 7.397

10.  Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation.

Authors:  Claudia Patrignani; David T Lafont; Valeria Muzio; Béatrice Gréco; Rob Hooft van Huijsduijnen; Paola F Zaratin
Journal:  J Inflamm (Lond)       Date:  2010-03-30       Impact factor: 4.981
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