OBJECTIVES: To compare the gastric emptying rate during normoglycemia with that during insulin-induced hypoglycemia in healthy subjects. RESEARCH DESIGN AND METHODS: In eight healthy subjects, the rate of gastric emptying of an isotope-labeled meal was assessed by a scintigraphic technique during normoglycemia and hypoglycemia, both controlled by an insulin-glucose clamp. RESULTS: The mean time taken to empty 50% of the test meal from the stomach (T50) for the solid phase was 43.0 +/- 20.0 min during normoglycemia, compared with 16.3 +/- 6.6 min during hypoglycemia, P < 0.001. The mean T50 for the liquid phase was 38.0 +/- 21.2 and 15.4 +/- 10.6 min, respectively, P < 0.001. CONCLUSIONS: Insulin-induced hypoglycemia increases the gastric emptying rate in healthy subjects.
OBJECTIVES: To compare the gastric emptying rate during normoglycemia with that during insulin-induced hypoglycemia in healthy subjects. RESEARCH DESIGN AND METHODS: In eight healthy subjects, the rate of gastric emptying of an isotope-labeled meal was assessed by a scintigraphic technique during normoglycemia and hypoglycemia, both controlled by an insulin-glucose clamp. RESULTS: The mean time taken to empty 50% of the test meal from the stomach (T50) for the solid phase was 43.0 +/- 20.0 min during normoglycemia, compared with 16.3 +/- 6.6 min during hypoglycemia, P < 0.001. The mean T50 for the liquid phase was 38.0 +/- 21.2 and 15.4 +/- 10.6 min, respectively, P < 0.001. CONCLUSIONS:Insulin-induced hypoglycemia increases the gastric emptying rate in healthy subjects.
Authors: Adrian Vella; Gerlies Bock; Paula D Giesler; Duane B Burton; Denise B Serra; Monica Ligueros Saylan; Carolyn F Deacon; James E Foley; Robert A Rizza; Michael Camilleri Journal: Clin Endocrinol (Oxf) Date: 2008-03-10 Impact factor: 3.478
Authors: Nam Nguyen; Katrina Ching; Robert Fraser; Marianne Chapman; Richard Holloway Journal: Intensive Care Med Date: 2007-10-02 Impact factor: 17.440
Authors: Palash Kar; Karen L Jones; Mark P Plummer; Yasmine Ali Abdelhamid; Emma J Giersch; Matthew J Summers; Seva Hatzinikolas; Simon Heller; Michael Horowitz; Adam M Deane Journal: J Clin Endocrinol Metab Date: 2017-11-01 Impact factor: 5.958