Literature DB >> 8585946

Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1.

R Hromas1, B Davis, F J Rauscher, M Klemsz, D Tenen, S Hoffman, D Xu, J F Morris.   

Abstract

Transcriptional regulators control much of hematopoiesis. One such transcriptional regulator is the myeloid zinc finger gene MZF-1. MZF-1 has been localized to the telomere of chromosome 19q, where a large number of related zinc finger genes reside. It has been found to be essential in granulopoiesis. It is a bi-functional transcriptional regulator, repressing transcription in non-hematopoietic cells, and activating transcription in cells of hematopoietic origins. Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. In co-transfection experiments MZF-1 has been found to regulate transcription from the CD34 promoter.

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Year:  1996        PMID： 8585946     DOI： 10.1007/978-3-642-85232-9_16

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  30 in total

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