Neurobiology of muscle fatigue. Advances and issues.

Throughout this epilogue, we have emphasized that rapid advances in understanding of neural and muscular aspects of fatigue have occurred since the 1980 London Symposium. However, in each instance of progress, from the single muscle fiber to the forebrain, the application of more precise techniques have raised important new questions. Neuroscientists and muscle physiologists have expanded opportunities for rigorous study of a topic of major scientific and social importance.