Effect of H1 and H2 receptor antagonists on the serum activity of gamma-glutamyltransferase during liver regeneration after partial hepatectomy in rats.

Chronic administration of a low dose of the histamine H1 receptor antagonist terfenadine (2 mg/kg/day) induced an increase in gamma-glutamyltransferase serum activity in rats, 360 h after partial hepatectomy while the enzymatic activity appeared not to be affected during liver regeneration following treatment with the histamine H2 receptor antagonist cimetidine (20 mg/kg/day).