Literature DB >> 8584023

Prolactin receptor is associated with c-src kinase in rat liver.

J J Berlanga1, J A Fresno Vara, J Martín-Pérez, J P García-Ruiz.   

Abstract

The mechanism of action of the pituitary hormone PRL was studied in hepatocytes of lactating rats. PRL receptor immune complexes obtained from liver lysates have an associated tyrosine kinase activity. The tyrosine kinase has been identified in isolated hepatocytes as pp60c-src. Incubation of hepatocytes with PRL induces the association of PRL receptor with pp60c-src and the resultant stimulation of its tyrosine kinase activity. Furthermore, PRL stimulates the gene expression of c-fos, c-jun, and c-src. All of these findings support the idea that the pp60c-src tyrosine kinase participates in the early steps of the PRL intracellular signaling that promotes cell growth in liver cells.

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Year:  1995        PMID： 8584023     DOI： 10.1210/mend.9.11.8584023

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN： 0888-8809


  17 in total

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Review 4.  Prolactin as a mitogen in mammary cells.

Authors:  R Das; B K Vonderhaar
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-01       Impact factor: 2.673

Review 5.  The prolactin/growth hormone receptor family: structure/function relationships.

Authors:  V Goffin; P A Kelly
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-01       Impact factor: 2.673

Review 6.  The role of prolactin in mammary carcinoma.

Authors:  Charles V Clevenger; Priscilla A Furth; Susan E Hankinson; Linda A Schuler
Journal:  Endocr Rev       Date:  2003-02       Impact factor: 19.871

Review 7.  Prolactin regulation of the prostate gland: a female player in a male game.

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9.  Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect.

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Journal:  Mol Endocrinol       Date:  2007-11-01

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Journal:  Fish Physiol Biochem       Date:  2009-09-10       Impact factor: 2.794
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