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Literature DB >> 858378

Neuroendocrine effects of a non-steroidal compound of testicular origin.

F Iturriza, M R Carlini, F Piva, L Martini.

Abstract

The effects of the compound (+)-1,4-diphenylbutane-2,3-diol (DPB, synthetized in the testes) on gonadotropin secretion have been studied in castrated male rats. DPB, when injected subcutaneously, does not modify serum levels of LH and FSH. On the contrary, the local implantation of DPB in the median eminence of the hypothalamus results in a significant elevation of serum FSH. It is suggested that DPB may play a physiological role in the control of FSH release.

Entities: Chemical Disease Species

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Year: 1977 PMID： 858378 DOI： 10.1007/BF02002849

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

11 in total

1. Studies on the relationship between spermatogenesis and urinary levels of follicle stimulating hormone and luteinizing hormone in oligospermic men.

Authors: P Christiansen
Journal: Acta Endocrinol (Copenh) Date: 1975-01

2. Selective suppression of FSH by testicular extracts.

Authors: E J Keogh; V W Lee; G C Rennie; H G Burger; B Hudson; D M De Kretser
Journal: Endocrinology Date: 1976-04 Impact factor: 4.736

3. Evidence for the existence in spermatozoa of a factor inhibiting the follicle stimulating hormone releasing hormone synthesis.

Authors: G Lugaro; M M Casellato; G Mazzola; G Fachini; G Carrea
Journal: Neuroendocrinology Date: 1974 Impact factor: 4.914

9. Periovulatory patterns of rat serum follicle stimulating hormone and luteinizing hormone during the normal estrous cycle as revealed by radioimmunoassays: effects of pentobarbital.

Authors: T A Daane; A F Parlow
Journal: Endocrinology Date: 1971-03 Impact factor: 4.736

10. Aromatization of androstenedione by the anterior hypothalamus of adult male and female rats.

Authors: F Naftolin; K J Ryan; Z Petro
Journal: Endocrinology Date: 1972-01 Impact factor: 4.736

Neuroendocrine effects of a non-steroidal compound of testicular origin.

1. Studies on the relationship between spermatogenesis and urinary levels of follicle stimulating hormone and luteinizing hormone in oligospermic men.

2. Selective suppression of FSH by testicular extracts.

3. Evidence for the existence in spermatozoa of a factor inhibiting the follicle stimulating hormone releasing hormone synthesis.

4. The feedback control of luteinizing hormone in normal adult men.

5. Aromatization of androstenedione and testosterone by rhesus monkey hypothalamus and limbic system.

6. Inhibitory effect of 5 -reduced metabolites of testosterone on gonadotrophin secretion.

7. The transformation of testosterone into dihydrotestosterone by the brain and the anterior pituitary.

8. Radioimmunoassay for rat luteinizing hormone with antiovine LH serum and ovine LH-131-I.

9. Periovulatory patterns of rat serum follicle stimulating hormone and luteinizing hormone during the normal estrous cycle as revealed by radioimmunoassays: effects of pentobarbital.

10. Aromatization of androstenedione by the anterior hypothalamus of adult male and female rats.