Literature DB >> 858144

The development of prostatic adenocarcinoma in Nb rats following prolonged sex hormone administration.

R L Noble.   

Abstract

The low spontaneous incidence of grossly recognizable adenocarcinomas of the dorsal lobe of the prostate in Nb rats over 13 months old (0.45%) was increased to 18.38% in 130 rats by prolonged treatment with pellets of suitable sex hormones. Although testosterone propionate alone was effective, if the testosterone propionate was combined with treatment by estrone carcinomas of the prostate occurred after a shorter interval. Tumors tended to metastasize and transplanted readily, and all were autonomous, with a single exception that exhibited the growth pattern of a typical estrogen-dependent tumor.

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Year:  1977        PMID： 858144

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  55 in total

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2.  Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis.

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4.  Results of a study to correlate serum prostate specific antigen and reproductive hormone levels in patients with localized prostate cancer.

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Review 5.  Prostate cancer: 3. Individual risk factors.

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Review 6.  Fibroblasts are critical determinants in prostatic cancer growth and dissemination.

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7.  Novel biomarkers for risk of prostate cancer: results from a case-control study.

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8.  Quantified gene expression levels for phase I/II metabolizing enzyme and estrogen receptor levels in benign prostate from cohorts designated as high-risk (UK) versus low-risk (India) for adenocarcinoma at this organ site: a preliminary study.

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9.  Identification of novel androgen-responsive genes by sequencing of LongSAGE libraries.

Authors:  Tammy L Romanuik; Gang Wang; Robert A Holt; Steven J M Jones; Marco A Marra; Marianne D Sadar
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10.  Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer.

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