Literature DB >> 8581420

Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.

W C Groutas1, M J Brubaker, L S Chong, R Venkataraman, H Huang, J B Epp, R Kuang, J R Hoidal.   

Abstract

Structure-activity relationship study and in vitro biochemical studies with human leukocyte elastase, cathepsin G and proteinase 3 were conducted using a series of succinimide derivatives.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8581420     DOI： 10.1016/0968-0896(95)00024-b

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold.

Authors:  Guijia He; Dengfeng Dou; Liuqing Wei; Kevin R Alliston; William C Groutas
Journal:  Eur J Med Chem       Date:  2010-06-30       Impact factor: 6.514

2.  Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3.

Authors:  Dengfeng Dou; Guijia He; Yi Li; Zhong Lai; Liuqing Wei; Kevin R Alliston; Gerald H Lushington; David M Eichhorn; William C Groutas
Journal:  Bioorg Med Chem       Date:  2009-12-29       Impact factor: 3.641

3.  N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases.

Authors:  Jelena Konstantinović; Samir Yahiaoui; Alaa Alhayek; Jörg Haupenthal; Esther Schönauer; Anastasia Andreas; Andreas M Kany; Rolf Müller; Jesko Koehnke; Fabian K Berger; Markus Bischoff; Rolf W Hartmann; Hans Brandstetter; Anna K H Hirsch
Journal:  J Med Chem       Date:  2020-06-17       Impact factor: 7.446

4.  Effects of chirality on the antifungal potency of methylated succinimides obtained by Aspergillus fumigatus biotransformations. comparison with racemic ones.

Authors:  Maximiliano Sortino; Agustina Postigo; Susana Zacchino
Journal:  Molecules       Date:  2013-05-15       Impact factor: 4.411
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.