Literature DB >> 8581353

Vasopressor effect of lysophosphatidic acid on spontaneously hypertensive rats and Wistar Kyoto rats.

A Tokumura1, T Yotsumoto, Y Masuda, S Tanaka.   

Abstract

Intravenous injection of lysophosphatidic acid (LPA, 1-acyl-sn-glycerol-3-phosphate) into conscious, spontaneously hypertensive rats (SHR) promptly elicited hypertension in a dose-dependent manner, its effect being significantly higher than in conscious, age-matched Wistar Kyoto strain rats (WKY). There was, however, no difference between the potencies of LPA in raising the mean blood pressure of SHR and WKY anesthetized with pentobarbital. The releases of norepinephrine, angiotensin II, prostaglandin and leukotriene were found not to be involved in the vasopressor effect of LPA in SHR, although thromboxane seemed to be slightly related to the action of LPA.

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Year:  1995        PMID： 8581353

Source DB:  PubMed          Journal:  Res Commun Mol Pathol Pharmacol        ISSN： 1078-0297


  8 in total

1.  LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction.

Authors:  Péter Tibor Dancs; Éva Ruisanchez; Andrea Balogh; Cecília Rita Panta; Zsuzsanna Miklós; Rolf M Nüsing; Junken Aoki; Jerold Chun; Stefan Offermanns; Gábor Tigyi; Zoltán Benyó
Journal:  FASEB J       Date:  2017-01-09       Impact factor: 5.191

2.  Lysophosphatidic acid acts on LPA1 receptor to increase H2 O2 during flow-induced dilation in human adipose arterioles.

Authors:  Dawid S Chabowski; Andrew O Kadlec; Karima Ait-Aissa; Joseph C Hockenberry; Paul J Pearson; Andreas M Beyer; David D Gutterman
Journal:  Br J Pharmacol       Date:  2018-10-11       Impact factor: 8.739

3.  The early- and late stages in phenotypic modulation of vascular smooth muscle cells: differential roles for lysophosphatidic acid.

Authors:  Huazhang Guo; Natalia Makarova; Yunhui Cheng; Shuyu E; Rui-Rui Ji; Chunxiang Zhang; Patricia Farrar; Gabor Tigyi
Journal:  Biochim Biophys Acta       Date:  2008-06-13

Review 4.  Cyclic phosphatidic acid - a unique bioactive phospholipid.

Authors:  Yuko Fujiwara
Journal:  Biochim Biophys Acta       Date:  2008-05-23

5.  Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.

Authors:  Éva Ruisanchez; Péter Dancs; Margit Kerék; Tamás Németh; Bernadett Faragó; Andrea Balogh; Renukadevi Patil; Brett L Jennings; Károly Liliom; Kafait U Malik; Alan V Smrcka; Gabor Tigyi; Zoltán Benyó
Journal:  FASEB J       Date:  2013-11-18       Impact factor: 5.191

6.  Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats.

Authors:  X Chen; F J Walther; R van Boxtel; E H Laghmani; R M A Sengers; G Folkerts; M C DeRuiter; E Cuppen; G T M Wagenaar
Journal:  Acta Physiol (Oxf)       Date:  2015-11-11       Impact factor: 6.311

7.  Lysophosphatidic acid increases the electrophysiological instability of adult rabbit ventricular myocardium by augmenting L-type calcium current.

Authors:  Yong Wei; Li-qun Zhao; Bao-zhen Qi; Xing Xiao; Li He; Gen-qing Zhou; Song-wen Chen; Hong-li Li; Lei Ruan; Cun-tai Zhang; Shao-wen Liu
Journal:  PLoS One       Date:  2012-09-21       Impact factor: 3.240

8.  Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction.

Authors:  Marius C Staiculescu; Francisco I Ramirez-Perez; Jorge A Castorena-Gonzalez; Zhongkui Hong; Zhe Sun; Gerald A Meininger; Luis A Martinez-Lemus
Journal:  Front Physiol       Date:  2014-10-31       Impact factor: 4.566
  8 in total

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