Literature DB >> 8580445

Cholecystokinin enhances the acoustic startle response in rats.

M Fendt1, M Koch, M Kungel, H U Schnitzler.   

Abstract

The present study examined the effects of the neuropeptide cholecystokinin (CCK) on neurones of the caudal pontine reticular nucleus (PnC), which mediates the acoustic startle response (ASR) in rats. Electrophysiological experiments revealed an excitatory effect of CCK on acoustically responsive neurones in the PnC. On the behavioural level, CCK also enhanced the ASR. Since the PnC is not only an obligatory relay station of the brain circuit mediating the ASR, but also receives modulatory input from brain areas involved in the expression of fear and anxiety, the enhancement of the ASR by CCK could be interpreted as an anxiogenic-like effect of this peptide.

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Year:  1995        PMID： 8580445     DOI： 10.1097/00001756-199510010-00030

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  7 in total

1.  Activation of amygdala cholecystokininB receptors potentiates the acoustic startle response in the rat.

Authors:  P W Frankland; S A Josselyn; J Bradwejn; F J Vaccarino; J S Yeomans
Journal:  J Neurosci       Date:  1997-03-01       Impact factor: 6.167

Review 2.  Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y.

Authors:  Mallory E Bowers; Dennis C Choi; Kerry J Ressler
Journal:  Physiol Behav       Date:  2012-03-10

3.  Somatostatin in the pontine reticular formation modulates fear potentiation of the acoustic startle response: an anatomical, electrophysiological, and behavioral study.

Authors:  M Fendt; M Koch; H U Schnitzler
Journal:  J Neurosci       Date:  1996-05-01       Impact factor: 6.167

4.  Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses.

Authors:  Eric D Gaier; Ramona M Rodriguiz; Xin-Ming M Ma; Shobhana Sivaramakrishnan; Danielle Bousquet-Moore; William C Wetsel; Betty A Eipper; Richard E Mains
Journal:  J Neurosci       Date:  2010-10-13       Impact factor: 6.167

5.  Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort.

Authors:  Trina M Norden-Krichmar; Ian R Gizer; Evelyn Phillips; Kirk C Wilhelmsen; Nicholas J Schork; Cindy L Ehlers
Journal:  Twin Res Hum Genet       Date:  2015-11-26       Impact factor: 1.587

6.  Visuoauditory Associative Memory Established with Cholecystokinin Under Anesthesia Is Retrieved in Behavioral Contexts.

Authors:  Zicong Zhang; Xuejiao Zheng; Wenjian Sun; Yujie Peng; Yiping Guo; Danyi Lu; Yilin Zheng; Xiao Li; Peter Jendrichovsky; Peng Tang; Ling He; Min Li; Qing Liu; Fuqiang Xu; Gabriel Ng; Xi Chen; Jufang He
Journal:  J Neurosci       Date:  2020-01-24       Impact factor: 6.167

7.  Cholecystokinin from the entorhinal cortex enables neural plasticity in the auditory cortex.

Authors:  Xiao Li; Kai Yu; Zicong Zhang; Wenjian Sun; Zhou Yang; Jingyu Feng; Xi Chen; Chun-Hua Liu; Haitao Wang; Yi Ping Guo; Jufang He
Journal:  Cell Res       Date:  2013-12-17       Impact factor: 25.617
  7 in total

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