Literature DB >> 8577454

Retinal pigment epithelium cell culture as a model for evaluation of the toxicity of tamoxifen and chloroquine.

T Toimela1, H Tähti, L Salminen.   

Abstract

The retinal pigment epithelium (RPE) removes the outer segments of photoreceptor cells by phagocytosis. We studied the effects of tamoxifen and chloroquine on the activity of the lysosomal enzymes N-acetyl-beta-glucosaminidase and cathepsin D in RPE in vitro to evaluate the possible eye toxicity caused by these drugs. The results show decreases in the activities of lysosomal enzymes after drug exposure. The enzymes tested seemed to be more sensitive to tamoxifen than to chloroquine. A profound decrease in the activities of the lysosomal enzymes only started at concentrations above therapeutic dose levels.

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Year:  1995        PMID： 8577454     DOI： 10.1159/000267861

Source DB:  PubMed          Journal:  Ophthalmic Res        ISSN： 0030-3747            Impact factor:   2.892


  10 in total

1.  2-Phenyl-APB-144-Induced Retinal Pigment Epithelium Degeneration and Its Underlying Mechanisms.

Authors:  Shin-ichiro Hirai; Hiroaki Kurashima; Daisuke Nakamura; Tomoko Komatsu; Yuki Yasuda; Sayo Habashita-Obata; Sanae Ichikawa; Osamu Katsuta; Takao Iwawaki; Kenji Kohno
Journal:  J Ocul Pharmacol Ther       Date:  2015-08-27       Impact factor: 2.671

2.  Electrophysiological evaluation of visual pathways in paclitaxel-treated patients.

Authors:  V Scaioli; A Caraceni; C Martini; S Curzi; G Capri; G Luca
Journal:  J Neurooncol       Date:  2005-08-25       Impact factor: 4.130

Review 3.  Hydroxychloroquine retinopathy.

Authors:  I H Yusuf; S Sharma; R Luqmani; S M Downes
Journal:  Eye (Lond)       Date:  2017-03-10       Impact factor: 3.775

4.  Low concentrations of chloroquine and 3-methyladenine suppress the viability of retinoblastoma cells synergistically with vincristine independent of autophagy inhibition.

Authors:  Xiao-Yu Zheng; Lin-Jie Li; Wei Li; Pei-Fang Jiang; Hong-Qiang Shen; Ying-Hu Chen; Xi Chen
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-09-03       Impact factor: 3.117

5.  Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.

Authors:  Ji Liu; Wennan Lu; David Reigada; Jonathan Nguyen; Alan M Laties; Claire H Mitchell
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-02       Impact factor: 4.799

6.  The salubrious effect of tamoxifen [correction of Tamaxifen] on serum marker enzymes, glycoproteins, and lysosomal enzymes level in breast cancer woman.

Authors:  M Thangaraju; J Rameshbabu; H Vasavi; S Ilanchezhian; R Vinitha; P Sachdanandam
Journal:  Mol Cell Biochem       Date:  1998-08       Impact factor: 3.396

7.  Retinal function in patients treated with tamoxifen.

Authors:  Sung Eun Song Watanabe; Adriana Berezovsky; Márcia Motono; Paula Yuri Sacai; Josenilson Martins Pereira; Juliana Maria Ferraz Sallum; Luiz Henrique Gebrim; Solange Rios Salomão
Journal:  Doc Ophthalmol       Date:  2010-04       Impact factor: 2.379

8.  Potential effect of natural and anabolizan steroids in elderly patient with COVID-19.

Authors:  Fatih Karaahmet; Ozgur Zeliha Karaahmet
Journal:  Med Hypotheses       Date:  2020-04-22       Impact factor: 1.538

Review 9.  Hydroxychloroquine and Covid-19: A Cellular and Molecular Biology Based Update.

Authors:  Amit Pal; Anil Pawar; Kalyan Goswami; Praveen Sharma; Rajendra Prasad
Journal:  Indian J Clin Biochem       Date:  2020-06-10

Review 10.  The controversial therapeutic journey of chloroquine and hydroxychloroquine in the battle against SARS-CoV-2: A comprehensive review.

Authors:  Subham Das; Anu Kunnath Ramachandran; Sumit Raosaheb Birangal; Saleem Akbar; Bahar Ahmed; Alex Joseph
Journal:  Med Drug Discov       Date:  2021-03-10
  10 in total

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